Lead, selenium and nickel concentrations in epithelial ovarian cancer, borderline ovarian tumor and healthy ovarian tissues.

Autor: Canaz E; Gynecologic Oncology, Department of Obstetrics and Gynecology, Sisli Hamidiye Etfal Training and Research Hospital, Halaskargazi Cd. Etfal, Sisli, Sk. 34371 Turkey. Electronic address: emelcanaz@gmail.com., Kilinc M; Department of Biochemistry, Kahramanmaras Sutcu Imam University School of Medicine, Kahramanmaras, Turkey., Sayar H; Department of Pathology, Kahramanmaras Sutcu Imam University School of Medicine, Kahramanmaras, Turkey., Kiran G; Department of Obstetrics and Gynecology, Umraniye Training and Research Hospital, Istanbul, Turkey., Ozyurek E; Department of Obstetrics and Gynecology, Bagcilar Training and Research Hospital, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2017 Sep; Vol. 43, pp. 217-223. Date of Electronic Publication: 2017 May 17.
DOI: 10.1016/j.jtemb.2017.05.003
Abstrakt: Objective: Wide variation exists in ovarian cancer incidence rates suggesting the importance of environmental factors. Due to increasing environmental pollution, trace elements and heavy metals have drawn attention in studies defining the etiology of cancer, but scant data is available for ovarian cancer. Our aim was to compare the tissue concentrations of lead, selenium and nickel in epithelial ovarian cancer, borderline tumor and healthy ovarian tissues.
Methods: The levels of lead, selenium and nickel were estimated using atomic absorption spectrophotometry in formalin-fixed paraffin-embedded tissue samples. Tests were carried out in 20 malignant epithelial ovarian cancer, 15 epithelial borderline tumor and 20 non-neoplastic healthy ovaries. Two samples were collected for borderline tumors, one from papillary projection and one from the smooth surface of cyst wall.
Results: Pb and Ni concentrations were found to be higher both in malignant and borderline tissues than those in healthy ovaries. Concentrations of Pb and Ni in malignant tissues, borderline papillary projections and capsular tissue samples were not different. Comparison of Se concentrations of malignant, borderline and healthy ovarian tissues did not reveal statistical difference. Studied metal levels were not found to be different in either papillary projection or in cyst wall of the borderline tumors.
Conclusions: This study revealed the accumulation of lead and nickel in ovarian tissue is associated with borderline and malignant proliferation of the surface epithelium. Accumulation of these metals in epithelial ovarian cancer and borderline ovarian tumor has not been demonstrated before.
(Copyright © 2017 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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