TRPM channels as potential therapeutic targets against pro-inflammatory diseases.

Autor: Zierler S; Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, Germany. Electronic address: susanna.zierler@lrz.uni-muenchen.de., Hampe S; Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, Germany., Nadolni W; Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, Germany.
Jazyk: angličtina
Zdroj: Cell calcium [Cell Calcium] 2017 Nov; Vol. 67, pp. 105-115. Date of Electronic Publication: 2017 May 03.
DOI: 10.1016/j.ceca.2017.05.002
Abstrakt: The immune system protects our body against foreign pathogens. However, if it overshoots or turns against itself, pro-inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, or diabetes develop. Ions, the most basic signaling molecules, shape intracellular signaling cascades resulting in immune cell activation and subsequent immune responses. Mutations in ion channels required for calcium signaling result in human immunodeficiencies and highlight those ion channels as valued targets for therapies against pro-inflammatory diseases. Signaling pathways regulated by melastatin-like transient receptor potential (TRPM) cation channels also play crucial roles in calcium signaling and leukocyte physiology, affecting phagocytosis, degranulation, chemokine and cytokine expression, chemotaxis and invasion, as well as lymphocyte development and proliferation. Therefore, this review discusses their regulation, possible interactions and whether they can be exploited as targets for therapeutic approaches to pro-inflammatory diseases.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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