Biophysical and biological studies of some polymer grafted metallo-intercalators.

Autor: Manojkumar Y; School of Chemistry, Bharathidasan University, Tiruchirappalli-620 024, India., Ambika S; School of Chemistry, Bharathidasan University, Tiruchirappalli-620 024, India., Senthilkumar R; Department of Biosciences, Cell biology, Åbo Akademi University, Turku, Finland., Arunachalam S; School of Chemistry, Bharathidasan University, Tiruchirappalli-620 024, India. Electronic address: arunasurf@yahoo.com.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2017 Aug 01; Vol. 156, pp. 320-329. Date of Electronic Publication: 2017 May 15.
DOI: 10.1016/j.colsurfb.2017.05.037
Abstrakt: Two water-soluble polymer-copper(II) complexes, [Cu(ip) 2 (BPEI)](ClO 4 ) 2 ·H 2 O (Complex 1) and [Cu(dppz) 2 BPEI](ClO 4 ) 2 ·H 2 O (Complex 2) with different degree of coordination have been synthesized and characterized. The interaction between the prepared complexes and CTDNA has been assessed by various physico-chemical methods The spectroscopic and the cyclic voltammetry studies have revealed that both the complexes interact with CTDNA through intercalation binding mode. Among the two complexes, Complex 2 has higher binding affinity with CTDNA. The antiproliferative activity of the complexes has been examined on human breast cancer cells, MDAMB231, adopting various techniques. The results indicate that both the polymer-copper(II) complexes are effective against the breast cancer cell line and the order of the activity is consistent with the DNA-binding ability.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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