NUT carcinoma presenting in the palate - a case report.
| Autor: | Bjornstrup LR; DDS, Resident in Oral & Maxillofacial Surgery, Rigshospitalet Copenhagen, Copenhagen, Denmark., Reibel J; Department of Oral Pathology, University of Copenhagen, Copenhagen, Denmark., Kiss K; Department of Pathology, Rigshospitalet, Copenhagen, Denmark., Schioedt M; Department of Oral & Maxillofacial Surgery, Rigshospitalet, Copenhagen, Denmark. |
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| Jazyk: | angličtina |
| Zdroj: | APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2017 Oct; Vol. 125 (10), pp. 933-936. Date of Electronic Publication: 2017 May 25. |
| DOI: | 10.1111/apm.12710 |
| Abstrakt: | NUT carcinomas (NC) are rare and aggressive tumours characterized by chromosomal rearrangements of the gene encoding for nuclear protein of the testis (NUT) located on chromosome 15q14. This article presents a case of a 60-year-old woman diagnosed with NC presenting as a fast growing primary tumour in the right palate. Further evaluation revealed a tumour mass in the lungs and widespread metastases. A review of the literature did not reveal earlier cases presenting in the palate. In order to improve early diagnosis it is suggested to perform immunohistochemical testing for NUT in all poorly differentiated carcinomas without glandular differentiation arising in the chest, and head and neck (Clin Cancer Res, 18, 2012, 5773). (© 2017 APMIS. Published by John Wiley & Sons Ltd.) |
| Databáze: | MEDLINE |
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