| Autor: |
Liu X; 1 Department of Radiology, Medical College of Wisconsin , Milwaukee, Wisconsin., Lauer KK; 2 Department of Anesthesiology, Medical College of Wisconsin , Milwaukee, Wisconsin., Ward BD; 3 Department of Biophysics, Medical College of Wisconsin , Milwaukee, Wisconsin., Roberts CJ; 2 Department of Anesthesiology, Medical College of Wisconsin , Milwaukee, Wisconsin., Liu S; 2 Department of Anesthesiology, Medical College of Wisconsin , Milwaukee, Wisconsin., Gollapudy S; 2 Department of Anesthesiology, Medical College of Wisconsin , Milwaukee, Wisconsin., Rohloff R; 4 Department of Neurology, Medical College of Wisconsin , Milwaukee, Wisconsin., Gross W; 2 Department of Anesthesiology, Medical College of Wisconsin , Milwaukee, Wisconsin., Xu Z; 3 Department of Biophysics, Medical College of Wisconsin , Milwaukee, Wisconsin., Chen G; 3 Department of Biophysics, Medical College of Wisconsin , Milwaukee, Wisconsin., Binder JR; 4 Department of Neurology, Medical College of Wisconsin , Milwaukee, Wisconsin., Li SJ; 3 Department of Biophysics, Medical College of Wisconsin , Milwaukee, Wisconsin., Hudetz AG; 5 Department of Anesthesiology and Center for Consciousness Science, University of Michigan , Ann Arbor, Michigan. |
| Abstrakt: |
Conscious perception relies on interactions between spatially and functionally distinct modules of the brain at various spatiotemporal scales. These interactions are altered by anesthesia, an intervention that leads to fading consciousness. Relatively little is known about brain functional connectivity and its anesthetic modulation at a fine spatial scale. Here, we used functional imaging to examine propofol-induced changes in functional connectivity in brain networks defined at a fine-grained parcellation based on a combination of anatomical and functional features. Fifteen healthy volunteers underwent resting-state functional imaging in wakeful baseline, mild sedation, deep sedation, and recovery of consciousness. Compared with wakeful baseline, propofol produced widespread, dose-dependent functional connectivity changes that scaled with the extent to which consciousness was altered. The dominant changes in connectivity were associated with the frontal lobes. By examining node pairs that demonstrated a trend of functional connectivity change between wakefulness and deep sedation, quadratic discriminant analysis differentiated the states of consciousness in individual participants more accurately at a fine-grained parcellation (e.g., 2000 nodes) than at a coarse-grained parcellation (e.g., 116 anatomical nodes). Our study suggests that defining brain networks at a high granularity may provide a superior imaging-based distinction of the graded effect of anesthesia on consciousness. |
