Association Between Coronary Artery Disease and MicroRNA: Literature Review and Clinical Perspective.

Autor:	Malik R; Internal Medicine, Mount Sinai Medical Center, Miami Beach, Florida., Mushtaque RS; Center for Healthcare Advancement & Outcomes Research, Baptist Health Medical Group., Siddiqui UA; Center for Healthcare Advancement & Outcomes Research, Baptist Health Medical Group., Younus A; Center for Healthcare Advancement & Outcomes Research, Baptist Health Medical Group., Aziz MA; Center for Healthcare Advancement & Outcomes Research, Baptist Health Medical Group., Humayun C; Center for Healthcare Advancement & Outcomes Research, Baptist Health Medical Group., Mansoor K; Center for Healthcare Advancement & Outcomes Research, Baptist Health Medical Group., Latif MA; Weiss Memorial Hospital, Internal Medicine, University of Illinois at Chicago., Waheed S; Cardiology-University of Kansas Hospital & Medical Center, University of Kansas Hospital & Medical Center., Assad S; Department of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan., Khan I; Center for Healthcare Advancement & Outcomes Research, Baptist Health Medical Group., Bukhari SM; UPMC Mckeesport Internal Medicine Department, University of Pittsburgh Medical Center., DelCampo D; Center for Healthcare Advancement & Outcomes Research, Baptist Health Medical Group., Adus A; Center for Healthcare Advancement & Outcomes Research, Baptist Health Medical Group., Gannarapu S; Center for Healthcare Advancement & Outcomes Research, Baptist Health Medical Group.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2017 Apr 23; Vol. 9 (4), pp. e1188. Date of Electronic Publication: 2017 Apr 23.
DOI:	10.7759/cureus.1188
Abstrakt:	Background: Until recently, circulating micro-RNAs (miRNAs) have attracted major interest as novel biomarkers for the early diagnosis of coronary artery disease (CAD). This review article summarizes the available evidence on the correlation of micro-RNAs with both the clinical and subclinical coronary artery disease and highlights the necessity for exploring miRNAs as a potential diagnostic and prognostic biomarker of early CAD in an adult population. Methods: A systematic literature analysis and retrieval online systems Public/Publisher MEDLINE/ Excerpta Medica Database /Medical Literature Analysis and Retrieval System Online,(PUBMED/EMBASE/MEDLINE) search were conducted for relevant information. Search was limited to the articles published in English language and conducted on humans, January 2000 onwards. We excluded studies of heart surgery, coronary artery bypass grafting (CABG), angioplasty and heart transplant. Eighteen studies met the inclusion criteria. Results: Seven out of 18 studies were multivariate, i.e. adjusted for age, gender, body mass index (BMI), smoking, hypertension, diabetes, and blood lipid profiles, while the remaining twelve studies were univariate analysis. Different sources of miRNAs were used, i.e. plasma/serum, microparticles, whole blood, platelets, blood mononuclear intimal and endothelial progenitor cells were investigated. Fourteen out of 18 studies showed up-regulation of different miRNA in CAD patients and in vulnerable plaque disease. Four out of 18 studies showed both the up-regulation and down-regulation of miRNA in the population, while only three studies showed down-regulation of miRNA. Various sources and types of miRNA were used in each study. Conclusion: This review gives an extensive overview of up-regulation and down-regulation of miRNA in CAD and non-CAD patients. The pattern of miRNA regulation with respect to CAD/non-CAD study subjects varies across individual studies and different parameters, which could be the possible reason for this aberrancy. We suggest further trials be conducted in future for highlighting the role of miRNA in CAD, which may improve both the diagnostic and therapeutic approaches to stratifying CAD burden in the general population. Competing Interests: The authors have declared that no competing interests exist.
Databáze:	MEDLINE
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