Differential effects of amyloid-β peptide aggregation status on in vivo retinal neurotoxicity.
Autor: | Watts HR; Department of Medicine, Imperial College London, Charing Cross Campus, London, UK., Anderson P; Department of Medicine, Imperial College London, Charing Cross Campus, London, UK., Ma D; Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, UK., Philpott KL; Neurosciences, Centre of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK., Jen SM; Department of Medicine, Imperial College London, Charing Cross Campus, London, UK., Croucher M; Department of Medicine, Imperial College London, Charing Cross Campus, London, UK., Jen LS; Department of Medicine, Imperial College London, Charing Cross Campus, London, UK., Gentleman SM; Department of Medicine, Imperial College London, Charing Cross Campus, London, UK. |
---|---|
Jazyk: | angličtina |
Zdroj: | Eye and brain [Eye Brain] 2010 Sep 09; Vol. 2, pp. 121-137. Date of Electronic Publication: 2010 Sep 09 (Print Publication: 2010). |
DOI: | 10.2147/eb.s9902 |
Abstrakt: | The present study examined the relationship between amyloid beta (Aβ)-peptide aggregation state and neurotoxicity in vivo using the rat retinal-vitreal model. Following single unilateral intravitreal injection of either soluble Aβ Competing Interests: Disclosure The authors declare that there are no conflicts of interest in this work. |
Databáze: | MEDLINE |
Externí odkaz: |