Neutralization of Inflammation by Inhibiting In vitro and In vivo Secretory Phospholipase A 2 by Ethanol Extract of Boerhaavia diffusa L.
Autor: | Giresha AS; Department of Post Graduate Studies and Research in Biochemistry, Post Graduate Centre, Mangalore University, Kodagu, Karnataka, India., Pramod SN; Department of Studies and Research in Biochemistry, Laboratory of Immunomodulation and inflammation Biology, Sahyadri Science College (Autonomous), Kuvempu University, Shimoga, Karnataka, India., Sathisha AD; Department of Biochemistry, Institute of Biomedical Sciences, College of Health Sciences, Ayder Referral Hospital, Mekelle University, Mekelle, Ethiopia., Dharmappa KK; Department of Post Graduate Studies and Research in Biochemistry, Post Graduate Centre, Mangalore University, Kodagu, Karnataka, India. |
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Jazyk: | angličtina |
Zdroj: | Pharmacognosy research [Pharmacognosy Res] 2017 Apr-Jun; Vol. 9 (2), pp. 174-181. |
DOI: | 10.4103/0974-8490.204650 |
Abstrakt: | Background: Inflammation is a normal and necessary prerequisite to healing of the injured tissues. Inflammation contributes to all disease process including immunity, vascular pathology, trauma, sepsis, chemical, and metabolic injuries. The secretory phospholipase A Aims: The present study aims to investigate the inhibition of human sPLA Materials and Methods: The aqueous and different organic solvents extracts of B. diffusa were prepared and evaluated for human synovial fluid, human pleural fluid, as well as Vipera russelli and Naja naja venom sPLA Results: Among the extracts, the ethanol extract of B. diffusa (EEBD) showed the highest sPLA Conclusions: The findings suggest that the bioactive molecule/s from the EEBD is/are potentially responsible for the observed in vitro and in vivo sPLA Summary: The present study aims to investigate the inhibition of human sPLA Competing Interests: There are no conflicts of interest. |
Databáze: | MEDLINE |
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