An orthologous non-MHC locus in rats and mice is linked to CD4 + and CD8 + T-cell proportion.

Autor: Franckaert D; VIB Center for Brain &Disease Research, Leuven, Belgium.; Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium., Collin R; Division of Immunology-oncology, Maisonneuve-Rosemont Hospital, Research Center, Montréal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC, Canada., Dooley J; VIB Center for Brain &Disease Research, Leuven, Belgium.; Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium., Wallis RH; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Biological Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada., Poussier P; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Biological Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada., Liston A; VIB Center for Brain &Disease Research, Leuven, Belgium.; Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium., Hillhouse EE; Division of Immunology-oncology, Maisonneuve-Rosemont Hospital, Research Center, Montréal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC, Canada., Lesage S; Division of Immunology-oncology, Maisonneuve-Rosemont Hospital, Research Center, Montréal, QC, Canada.; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montréal, QC, Canada.
Jazyk: angličtina
Zdroj: Genes and immunity [Genes Immun] 2017 Sep; Vol. 18 (3), pp. 118-126. Date of Electronic Publication: 2017 May 25.
DOI: 10.1038/gene.2017.9
Abstrakt: CD4 + and CD8 + T cells have a central role in the immune system due to their ability to protect against infection and cancer development without targeting self. Consequently, changes in CD4 + and CD8 + T-cell homeostasis can be indicative of an array of serious illnesses, ranging from viral infections to autoimmune diseases. In addition to environmental influences, there is evidence for a genetic component regulating the proportion of CD4 + and CD8 + T cells in lymphoid organs. Indeed, identifying the genetic determinants defining the frequency of the T-cell subsets is critical as it may reveal a targetable genetic pathway to modulate CD4 + and CD8 + T-cell numbers, which could be of clinical relevance for multiple disease settings. In this study, we aim to uncover non-MHC genetic factors regulating the proportion of CD4 + and CD8 + T cells in lymphoid tissues. By investigating linkage analyses on three independent F2 cohorts, namely a rat F2 (BBDP × ACI.1U.LYP) cohort, a mouse 3A9 TCR transgenic F2 (B10.BR × NOD.H2 k ) cohort and a mouse F2 (C57BL/6 × FVB/N) cohort, we uncover an orthologous non-MHC locus on rat chromosome 1 and mouse chromosome 7 that is linked to T-cell proportion amongst total lymphocytes.
Databáze: MEDLINE
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