| Autor: |
Kozlov KL; Saint-Petersburg Institute of Bioregulation and Gerontology, Saint-Petersburg, 197110, Russian Federation; kozlov_kl@mail.ru., Bolotov II; Saint-Petersburg Institute of Bioregulation and Gerontology, Saint-Petersburg, 197110, Russian Federation; kozlov_kl@mail.ru., Linkova NS; Saint-Petersburg Institute of Bioregulation and Gerontology, Saint-Petersburg, 197110, Russian Federation; kozlov_kl@mail.ru.; Peter the Great Saint-Petersburg Polytechnic University, Saint-Petersburg, 195251, Russian Federation., Drobintseva AO; Saint-Petersburg Institute of Bioregulation and Gerontology, Saint-Petersburg, 197110, Russian Federation; kozlov_kl@mail.ru., Khavinson VK; Saint-Petersburg Institute of Bioregulation and Gerontology, Saint-Petersburg, 197110, Russian Federation; kozlov_kl@mail.ru.; Pavlov Institute of Physiology of RAS, Saint-Petersburg, 199034, Russian Federation.; I.I.Mechnikov State Medical Academy, Saint-Petersburg, 191015, Russian Federation., Dyakonov MM; Saint-Petersburg Institute of Bioregulation and Gerontology, Saint-Petersburg, 197110, Russian Federation; kozlov_kl@mail.ru., Kozina LS; Saint-Petersburg Institute of Bioregulation and Gerontology, Saint-Petersburg, 197110, Russian Federation; kozlov_kl@mail.ru. |
| Abstrakt: |
Peptide KED (Lys-Glu-Asp) has vasoprotective effects and is effective substance in treatment of of atherosclerosis and other cardio-vascular disorders in elderly people. One of the probable mechanisms of biological activity of this peptide is epigenetic genes regulation. These genes can coding proteins, which are markers of endothelium functional activity. The goal of investigation was to study the KED peptide effect on signal molecules expression in normal, atherosclerotic and restenotic endothelium in vitro. It was shown, that KED peptide has normalized endothelin-1 expression, which increased during atherosclerosis and restenosis. KED peptide also restorates cells interactions by connexin expression. Geroprotective effect of KED peptide is realized by increasing of sirtuin1 expression, which has took part in DNA reparation. |
