Relationship between quantitative and descriptive methods of studying blood flow through intrapulmonary arteriovenous anastomoses during exercise.

Autor: Duke JW; Northern Arizona University, Department of Biological Sciences, Flagstaff, AZ, USA. Electronic address: JJ.Duke@nau.edu., Elliott JE; University of Oregon, Department of Human Physiology, Eugene, OR, USA., Laurie SS; KBRwyle, NASA Johnson Space Center, Houston, TX, USA., Voelkel T; Sacred Heart Medical Center, Department of Nuclear Medicine, Springfield, OR, USA., Gladstone IM; Oregon Health and Sciences University, Department of Pediatrics, Portland, OR, USA., Fish MB; Sacred Heart Medical Center, Department of Nuclear Medicine, Springfield, OR, USA., Lovering AT; University of Oregon, Department of Human Physiology, Eugene, OR, USA.
Jazyk: angličtina
Zdroj: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2017 Sep; Vol. 243, pp. 47-54. Date of Electronic Publication: 2017 May 20.
DOI: 10.1016/j.resp.2017.05.006
Abstrakt: Several methods exist to study intrapulmonary arteriovenous anastomoses (IPAVA) in humans. Transthoracic saline contrast echocardiography (TTSCE), i.e., bubble scores, is minimally-invasive, but cannot be used to quantify the magnitude of blood flow through IPAVA (Q IPAVA ). Radiolabeled macroaggregates of albumin ( 99m Tc-MAA) have been used to quantify Q IPAVA in humans, but this requires injection of radioactive particles. Previous work has shown agreement between 99m Tc-MAA and TTSCE, but this has not been tested simultaneously in the same group of subjects. Thus, the purpose of this study was to determine if there was a relationship between Q IPAVA quantified with 99m Tc-MAA and bubble scores obtained with TTSCE. To test this, we used 99m Tc-MAA and TTSCE to quantify and detect Q IPAVA at rest and during exercise in humans. Q IPAVA significantly increased from rest to exercise using 99m Tc-MAA and TTSCE and there was a moderately-strong, but significant relationship between methods. Our data suggest that high bubble scores generally correspond with large Q IPAVA quantified with 99m Tc-MAA during exercise.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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