A systematic reactor design approach for the synthesis of active pharmaceutical ingredients.

Autor: Emenike VN; Institute of Energy and Process Systems Engineering, Technische Universität Braunschweig, Franz-Liszt-Straße 35, 38106 Braunschweig, Germany; PVZ-Center of Pharmaceutical Engineering, Franz-Liszt-Straße 35A, 38106 Braunschweig, Germany; International Max Planck Research School for Advanced Methods in Process and Systems Engineering, Sandtorstraße 1, 39106 Magdeburg, Germany., Schenkendorf R; Institute of Energy and Process Systems Engineering, Technische Universität Braunschweig, Franz-Liszt-Straße 35, 38106 Braunschweig, Germany; PVZ-Center of Pharmaceutical Engineering, Franz-Liszt-Straße 35A, 38106 Braunschweig, Germany., Krewer U; Institute of Energy and Process Systems Engineering, Technische Universität Braunschweig, Franz-Liszt-Straße 35, 38106 Braunschweig, Germany; PVZ-Center of Pharmaceutical Engineering, Franz-Liszt-Straße 35A, 38106 Braunschweig, Germany. Electronic address: u.krewer@tu-braunschweig.de.
Jazyk: angličtina
Zdroj: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2018 May; Vol. 126, pp. 75-88. Date of Electronic Publication: 2017 May 20.
DOI: 10.1016/j.ejpb.2017.05.007
Abstrakt: Today's highly competitive pharmaceutical industry is in dire need of an accelerated transition from the drug development phase to the drug production phase. At the heart of this transition are chemical reactors that facilitate the synthesis of active pharmaceutical ingredients (APIs) and whose design can affect subsequent processing steps. Inspired by this challenge, we present a model-based approach for systematic reactor design. The proposed concept is based on the elementary process functions (EPF) methodology to select an optimal reactor configuration from existing state-of-the-art reactor types or can possibly lead to the design of novel reactors. As a conceptual study, this work summarizes the essential steps in adapting the EPF approach to optimal reactor design problems in the field of API syntheses. Practically, the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene was analyzed as a case study of pharmaceutical relevance. Here, a small-scale tubular coil reactor with controlled heating was identified as the optimal set-up reducing the residence time by 33% in comparison to literature values.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: