Comparison of the cervista HPV HR test and luminex XMAP technology for the diagnosis of cervical intraepithelial neoplasia.

Autor: Zhao PY; Tenth People's Hospital of Tongji University, Shanghai, China; Nanjing Medical University, Nanjing, Jiangsu, China., Jiang HC; Tenth People's Hospital of Tongji University, Shanghai, China; Nanjing Medical University, Nanjing, Jiangsu, China., Li Y; Tenth People's Hospital of Tongji University, Shanghai, China., Wang JB; Tenth People's Hospital of Tongji University, Shanghai, China., Zhang TT; Tenth People's Hospital of Tongji University, Shanghai, China., Liu CH; Tenth People's Hospital of Tongji University, Shanghai, China., Song LW; Tenth People's Hospital of Tongji University, Shanghai, China., Cheng JJ; Tenth People's Hospital of Tongji University, Shanghai, China. Electronic address: 15950531787@163.com.
Jazyk: angličtina
Zdroj: European journal of obstetrics, gynecology, and reproductive biology [Eur J Obstet Gynecol Reprod Biol] 2017 Jul; Vol. 214, pp. 150-155. Date of Electronic Publication: 2017 May 16.
DOI: 10.1016/j.ejogrb.2017.05.012
Abstrakt: Objectives: This study was designed to compare the Cervista high risk (HR) human papillomavirus (HPV) test with Luminex XMAP technology for the detection of the relationship between HPV infection and cervical intraepithelial neoplasia.
Methods: In total, 3280 patients in a cervical specialty clinic were divided into two groups for either Cervista (1855 patients) or Luminex (1425 patients). Subsequent colposcopy examinations were performed in 1270 women with cytologic results showing ASCUS or higher level lesions. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were evaluated.
Results: The positive rates of the Cervista and Luminex groups were 61.48% and 67.43%, respectively, and occurrence in those 30-40 years old was most common. The typing of HPV showed that A9 positive cases were the most prevalent genotype (33.53%), followed by A5/A6 (16.44%) and A7 (11.37%) in the Cervista group, and HPV-16 was the most prevalent genotype (25.81%), followed by HPV-18 (18.6%) and HPV-31 (8.6%) in the Luminex group. Moreover, the overall concordance rate was 96.26% (95% confidence interval, 93.51-99.00%) in the 187 women with cytologic results of ASCUS or higher. There were no significant differences in the positive rates of HPV between the Cervista and Luminex groups, and both had a high sensitivity and NPV.
Conclusions: The results showed a high good concordance between the two methods in diagnostic accuracy. Among the patients in the cervical specialty clinic, both the A9 group of HPV and HPV-16 showed the highest positive rate. Cervista and Luminex shared similar a clinical value in the detection of CIN2 or higher.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: