Repeatability of [ 68 Ga]DKFZ11-PSMA PET Scans for Detecting Prostate-specific Membrane Antigen-positive Prostate Cancer.

Autor: Osborne JR; Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 77, New York, NY, 10065, USA. osbornej@mskcc.org.; Department of Radiology, Weill Cornell Medical College, New York, NY, USA. osbornej@mskcc.org., Kalidindi TM; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Punzalan BJ; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Gangangari K; Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 77, New York, NY, 10065, USA.; Department of Chemistry, Hunter College and PhD Program in Chemistry, The Graduate Center of the City University of New York, New York, NY, USA., Spratt DE; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA., Weber WA; Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 77, New York, NY, 10065, USA., Larson SM; Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 77, New York, NY, 10065, USA.; Department of Radiology, Weill Cornell Medical College, New York, NY, USA.; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pillarsetty NVK; Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 77, New York, NY, 10065, USA.; Department of Radiology, Weill Cornell Medical College, New York, NY, USA.; Department of Radiology, Memorial Sloan Kettering Cancer Center, Zuckerman Research Center, 417 East 68th Street, New York, NY, 10065, USA.
Jazyk: angličtina
Zdroj: Molecular imaging and biology [Mol Imaging Biol] 2017 Dec; Vol. 19 (6), pp. 944-951.
DOI: 10.1007/s11307-017-1091-9
Abstrakt: Purpose: We studied the effect of varying specific activity of [ 68 Ga]DKFZ-PSMA11 ([ 68 Ga]DP11) on repeated imaging of prostate-specific membrane antigen-positive (PSMA+) xenograft tumors.
Procedures: Athymic nude mice bearing PC3-PIP (PSMA+) and PC3 (PSMA-) bilateral flank tumors were assessed to study intra- and inter-day repeatability of [ 68 Ga]DP11 imaging in mice administered [ 68 Ga]DP11 or [ 67 Ga]DP11 (as a dilution tracer) using imaging and biodistribution studies.
Results: Region of interest (ROI) analysis of the [ 68 Ga]DP11 imaging study indicated that the uptake was constant on the same day or consecutive days. Prior imaging with [ 68 Ga]DP11 did not significantly influence the subsequent uptake of [ 68 Ga]DP11. Uptake of [ 68 Ga]DP11 (60 min) and [ 67 Ga]DP11 (24 h) in PC3-PIP tumors was 12.37 ± 4.19 %ID/g and 12.49 ± 6.88 %ID/g, respectively; [ 68 Ga]DP11 was 13.83 ± 3.77 and 17.76 ± 1.84 on same-day and 15.98 ± 5.82 %ID/g on second-day imaging.
Conclusions: This study demonstrates that [ 68 Ga]DP11, in a given PSMA+ lesion, is constant under several same-day or serial-day imaging conditions.
Databáze: MEDLINE
Externí odkaz: