The high-molecular weight multimer form of adiponectin is a useful marker of polycystic ovary syndrome in Bahraini Arab women.

Autor: Al-Awadi AM; Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain., Sarray S; Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain., Arekat MR; Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain., Saleh LR; Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain., Mahmood N; Department of Obstetrics and Gynecology, Salmaniya Medical Complex, Manama, Bahrain., Almawi WY; Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain. Electronic address: wassim@agu.edu.bh.
Jazyk: angličtina
Zdroj: Clinical nutrition ESPEN [Clin Nutr ESPEN] 2016 Jun; Vol. 13, pp. e33-e38. Date of Electronic Publication: 2016 Apr 20.
DOI: 10.1016/j.clnesp.2016.03.078
Abstrakt: Background & Aims: We tested if decreased total and high molecular weight (HMW)-adiponectin, and altered HMW/total adiponectin ratio (HMWR) constitute reliable markers of polycystic ovary syndrome (PCOS) among Bahraini Arab women.
Methods: Case-control study involving 122 Bahraini Arab women with PCOS and 89 ethnically-matched control women. PCOS was evaluated according to 2003 Rotterdam criteria. Total and HMW-adiponectin were measured by ELISA.
Results: Compared to controls, women with PCOS had significantly reduced plasma HMW-adiponectin, and HMWR, more so than total adiponectin. Logistic regression analysis revealed that HMW-adiponectin and HMWR, more than total adiponectin, were negatively associated with PCOS. ROC area-under-the-curve for predicting PCOS were larger for HMW-adiponectin (0.679 ± 0.037), and HMWR (0.653 ± 0.039), than total adiponectin (0.537 ± 0.041). Regression analysis confirmed the association of low HMW-adiponectin and HMWR with PCOS. HMW-adiponectin and HMWR inversely correlated with age, BMI, hirsutism, insulin, HOMA-IR, and positively correlated with serum LDL-cholesterol. Total adiponectin was negatively correlated with waist-hip ratio and serum LH levels.
Conclusions: Reduction in adiponectin plasma levels is an independent risk factor for PCOS. Changes in HMW-adiponectin serum levels and HMW/total adiponectin ratio are better markers for the presence of PCOS, when compared with total adiponectin.
(Copyright © 2016 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: