TRPV1 Channels in Immune Cells and Hematological Malignancies.

Autor:	Omari SA; School of Health Sciences, University of Tasmania, Launceston, TAS, Australia., Adams MJ; School of Health Sciences, University of Tasmania, Launceston, TAS, Australia., Geraghty DP; School of Health Sciences, University of Tasmania, Launceston, TAS, Australia. Electronic address: d.geraghty@utas.edu.au.
Jazyk:	angličtina
Zdroj:	Advances in pharmacology (San Diego, Calif.) [Adv Pharmacol] 2017; Vol. 79, pp. 173-198. Date of Electronic Publication: 2017 Mar 21.
DOI:	10.1016/bs.apha.2017.01.002
Abstrakt:	Transient receptor potential vanilloid-1 (TRPV1) is a member of the TRP family of channels that are responsible for nociceptive, thermal, and mechanical sensations. Originally associated exclusively with sensory neurons, TRPV1 is now known to be present in almost all organs, including cells of the immune system, where TRPV1 has been shown to play a pivotal role in inflammation and immunity. Monocytes, macrophages, and dendritic cells express TRPV1, with both mouse and human studies suggesting that TRPV1 activation protects against endotoxin-induced inflammation. In contrast, TRPV1 (and other TRP channels) appears to be required for T-cell receptor activation by mitogens. Additionally, studies in cell lines derived from hematological and other malignancies suggest altered expression/function of TRPV1 might serve as a target for novel cytotoxic therapies. (© 2017 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu