Toxicological aspects of interesterified fat: Brain damages in rats.

Autor: D'avila LF; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), RS, Brazil. Electronic address: liviadavila@hotmail.com., Dias VT; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), RS, Brazil. Electronic address: vel_td@hotmail.com., Vey LT; Programa de Pós-Graduação em Bioquímica Toxicológica, UFSM, RS, Brazil. Electronic address: luciana.taschetto@hotmail.com., Milanesi LH; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), RS, Brazil. Electronic address: laura-milanesi@hotmail.com., Roversi K; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), RS, Brazil. Electronic address: karineroversi_@hotmail.com., Emanuelli T; Programa de Pós-Graduação em Ciência e Tecnologia dos Alimentos, UFSM, RS, Brazil. Electronic address: tatiana.emanuelli@hotmail.com., Bürger ME; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), RS, Brazil; Programa de Pós-Graduação em Bioquímica Toxicológica, UFSM, RS, Brazil; Departamento de Fisiologia e Farmacologia, UFSM, RS, Brazil. Electronic address: marilise.burger@ufsm.br., Trevizol F; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), RS, Brazil. Electronic address: fatrevizol@yahoo.com.br., Maurer HL; Programa de Pós-Graduação em Ciência e Tecnologia dos Alimentos, UFSM, RS, Brazil. Electronic address: luanahmaurer@gmail.com.
Jazyk: angličtina
Zdroj: Toxicology letters [Toxicol Lett] 2017 Jul 05; Vol. 276, pp. 122-128. Date of Electronic Publication: 2017 May 17.
DOI: 10.1016/j.toxlet.2017.05.020
Abstrakt: In recent years, interesterified fat (IF) has been used to replace hydrogenated vegetable fat (HVF), rich in trans isomers, being found in processed foods. Studies involving IF have shown deleterious influences on the metabolic system, similarly to HVF, whereas no studies regarding its influence on the central nervous system (CNS) were performed. Rats from first generation born and maintained under supplementation (3g/Kg, p.o.) of soybean-oil or IF until adulthood were assessed on memory, biochemical and molecular markers in the hippocampus. IF group showed higher saturated fatty acids and linoleic acid and lower docosahexaenoic acid incorporation in the hippocampus. In addition, IF supplementation impaired short and long-term memory, which were related to increased reactive species generation and protein carbonyl levels, decreased catalase activity, BDNF and TrkB levels in the hippocampus. To the best of our knowledge, this is the first study to show that lifelong IF consumption may be related to brain oxidative damage, memory impairments and neurotrophins modifications, which collectively may be present indifferent neurological disorders. In fact, the use of IF in foods was intended to avoid damage from HVF consumption; however this substitute should be urgently reviewed, since this fat can be as harmful as trans fat.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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