The effects of non-invasive radiofrequency electric field hyperthermia on biotransport and biodistribution of fluorescent [60]fullerene derivative in a murine orthotopic model of breast adenocarcinoma.

Autor: Lapin NA; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA., Krzykawska-Serda M; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków 30-387, Poland., Dilliard S; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA; Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX 77005, USA., Mackeyev Y; Department of Chemistry, Rice University, Houston, TX 77005, USA., Serda M; Department of Chemistry, Rice University, Houston, TX 77005, USA; Institute of Chemistry, University of Silesia in Katowice, 40-006 Katowice, Poland., Wilson LJ; Department of Chemistry, Rice University, Houston, TX 77005, USA., Curley SA; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA; Department of Mechanical Engineering and Materials Science, Rice University, Houston, TX 77005, USA., Corr SJ; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA; Department of Chemistry, Rice University, Houston, TX 77005, USA; Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA. Electronic address: stuart.corr@bcm.edu.
Jazyk: angličtina
Zdroj: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2017 Aug 28; Vol. 260, pp. 92-99. Date of Electronic Publication: 2017 May 17.
DOI: 10.1016/j.jconrel.2017.05.022
Abstrakt: The aim of this study is to understand the combined and differential biokinetic effects of radiofrequency (RF) electric-field hyperthermia as an adjunctive therapy to [60]fullerene nanoparticle-based drug delivery systems in targeting the micro-vasculature and micro-environments of breast cancer tumors. Intravital microscopy (IVM) is an ideal tool to provide the spatial and temporal resolution needed for quantification in this investigation. The water-soluble and fluorescent [60]fullerene derivative (C 60 -serPF) was designed to be an amphiphilic nanostructure, which is able to cross several biological membranes and accumulate in tumor tissues by passing through abnormally leaky tumor blood vessels. To elucidate the coupled effects of the highly permeable, but heterogeneous tumor vasculature, with the permeabilizing effects of mild (40-42°C) hyperthermia produced by a local RF field, we controlled variables across tumor and non-tumor mammary gland microvasculature with and without application of RF hyperthermia in each condition. We notice that tumor tissue is characterized by more intense drug extravasation than in contralateral mammary fat pad tissue, which is consistent with enhanced permeability and retention (EPR) effects. The analysis of a permeability parameter (P app ), C 60 -serPF velocity, and the time of compound influx into the intra- and extra-vascular space suggest that mild RF hyperthermia can improve nanoparticle delivery into tumor tissue.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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