Hydrogen bonded charge transfer molecular salt (4-chloro anilinium-3-nitrophthalate) for photophysical and pharmacological applications.

Autor: Singaravelan K; Post-Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India., Chandramohan A; Post-Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India. Electronic address: depak1993@gmail.com., Saravanabhavan M; Post-Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India; Department of Chemistry, Dr.N.G.P. Institute of Technology, Coimbatore 48, India., Muthu Vijayan Enoch IV; Department of Chemistry/Nanoscience & Technology, Karunya University, Coimbatore 641114, Tamil Nadu, India., Suganthi VS; Department of Chemistry/Nanoscience & Technology, Karunya University, Coimbatore 641114, Tamil Nadu, India.
Jazyk: angličtina
Zdroj: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2017 Sep 05; Vol. 184, pp. 318-326. Date of Electronic Publication: 2017 May 10.
DOI: 10.1016/j.saa.2017.05.016
Abstrakt: Radical scavenging activity against DPPH radical and binding properties of a hydrogen bonded charge transfer molecular salt 4-chloro anilinium-3-nitrophthalate(CANP) with calf thymus DNA has been studied by electronic absorption and emission spectroscopy. The molecular structure and crystallinity of the CANP salt have been established by carried out powder and single crystal X-ray diffraction analysis which indicated that cation and anion are linked through strong N + H … O - type of hydrogen bond. FTIR spectroscopic study was carried out to know the various functional groups present in the crystal. 1 H and 13 C NMR spectra were recorded to further confirm the molecular structure of the salt crystal. The thermal stability of the title salt was established by TG/DTA analyses simultaneously on the powdered sample of the title crystal. Further, the CANP salt was examined against various bacteria and fungi strains which showed a remarkable antimicrobial activity compared to that of the standards Ciproflaxin and Clotrimazole. The results showed that the CANP salt could interact with CT-DNA through intercalation. Antioxidant studies of the substrates alone and synthesized CANP salt showed that the latter has been better radical scavenging activity than that of the former against DPPH radical. The third order nonlinear susceptibility of the CANP salt was established by the Z-scan study.
(Copyright © 2017. Published by Elsevier B.V.)
Databáze: MEDLINE
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