Myocardial protection with Glucose-Insulin-Potassium infusion during adult cardiac surgery.

Autor: Ahmad S; Dr. Suhail Ahmad, DA, MCPS, FCPS, M. Sc. Pain Medicine, Associate Professor of Anesthesia and Critical Care, CPE Institute of Cardiology Multan, Pakistan., Ahmad RA; Dr. Rana Altaf Ahmad, DA, FCPS, M. Sc. Pain Medicine, Professor of Anesthesia and Critical Care, Executive Director, CPE Institute of Cardiology Multan, Pakistan., Qureshi BA; Dr. Bilal Ahsan Qureshi, Associate Professor of Cardiology, CPE Institute of Cardiology Multan, Pakistan., Baig MAR; Mirza Ahmad Raza Baig, B. Sc. Hons CPT, Clinical Perfusionist, CPE Institute of Cardiology Multan, Pakistan.
Jazyk: angličtina
Zdroj: Pakistan journal of medical sciences [Pak J Med Sci] 2017 Mar-Apr; Vol. 33 (2), pp. 325-329.
DOI: 10.12669/pjms.332.12414
Abstrakt: Background & Objective: Recent meta-analysis reports have called for more randomized trials to evaluate the effectiveness of GIK solution in patients of cardiac surgery. So this study was conducted to evaluate the effectiveness of Glucose-insulin-potassium (GIK) solutions in non-diabetic patients undergoing coronary artery bypass grafting.
Methods: A total number of one hundred and sixty (160) patients were randomized into two equal groups; GIK Group and non-GIK group. In GIK group, 5% dextrose containing 70 IU/L regular insulin and 70 meq/L of potassium was administered. The infusion was started at a rate of 30 ml/hour after induction of anesthesia and before the start of cardiopulmonary bypass. The infusion was started again after removal of aortic cross clamp and was continued for six hours after the operation.
Results: In early post-operative period, peak CKMB levels were high in non-GIK group 48.50±19.79 IU/L versus 33.40±14.69 IU/L in GIK group (p-value <0.001). There was no statistically significant difference in requirements of inotropic support between the groups. The mean duration of inotropic support in GIK group was only 5.50±6.88 hours in GIK group and 8.64±7.74 hours in non-GIK group (p-value 0.008). Mean ventilation time in GIK group was 5.06±2.39 hours versus 6.55±3.58 hours in non-GIK group (p-value 0.002). Similarly, ICU stay period was also shorter in GIK group (p-value 0.01). We did not found any detrimental effect of GIK infusion on non-cardiac complications e.g. renal, pulmonary and neurologic complications.
Conclusion: Glucose-insulin-potassium (GIK) infusion has a beneficial role in myocardial protection and is associated with better post-operative outcomes without increasing the risk of non-cardiac complications.
Competing Interests: Declaration of Interest: None.
Databáze: MEDLINE
Externí odkaz: