Relation of antioxidant capacity of diet and markers of oxidative status with C-reactive protein and adipocytokines: a prospective study.

Autor: Stringa N; Department of Epidemiology, Erasmus MC, 3015 GE Rotterdam, The Netherlands., Brahimaj A; Department of Epidemiology, Erasmus MC, 3015 GE Rotterdam, The Netherlands., Zaciragic A; Department of Epidemiology, Erasmus MC, 3015 GE Rotterdam, The Netherlands., Dehghan A; Department of Epidemiology, Erasmus MC, 3015 GE Rotterdam, The Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC, 3015 GE Rotterdam, The Netherlands., Hofman A; Department of Epidemiology, Erasmus MC, 3015 GE Rotterdam, The Netherlands; Department of Epidemiology, Harvard T.H Chan School of Public Health, 02115 Boston, USA., Muka T; Department of Epidemiology, Erasmus MC, 3015 GE Rotterdam, The Netherlands. Electronic address: t.muka@erasmusmc.nl., Kiefte-de Jong JC; Department of Epidemiology, Erasmus MC, 3015 GE Rotterdam, The Netherlands; Department of Global Public Health, Leiden University College, 2595 DG The Hague, The Netherlands., Franco OH; Department of Epidemiology, Erasmus MC, 3015 GE Rotterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Metabolism: clinical and experimental [Metabolism] 2017 Jun; Vol. 71, pp. 171-181. Date of Electronic Publication: 2017 Mar 31.
DOI: 10.1016/j.metabol.2017.03.015
Abstrakt: Background: The role of dietary antioxidants and plasma oxidant-antioxidant status in low-grade chronic inflammation and adipocytokine levels is not established yet.
Objectives: We aimed to evaluate whether total dietary antioxidant capacity (assessed by dietary ferric reducing antioxidant potential (FRAP)), serum uric acid (UA) and gamma glutamyltransferase (GGT) were associated with low-grade chronic inflammation and circulating adipocytokines.
Methods: Data of 4506 participants aged ≥55years from the Rotterdam Study were analyzed. Baseline (1990-1993) FRAP score was assessed by a food frequency questionnaire. Baseline UA and GGT levels were assessed in non-fasting serum samples. Serum high sensitivity C-reactive protein (hs-CRP) was measured at baseline and 10years later. Plasma leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1) and resistin levels were assessed 10years later.
Results: A high FRAP score was associated with lower levels of UA and GGT. Overall, no association was found between FRAP and hs-CRP levels. FRAP score was associated with lower levels of leptin and PAI-1, higher levels of adiponectin, and no difference in resistin levels. Increased levels of UA were associated with higher levels of hs-CRP, PAI-1 and leptin; lower levels of adiponectin and no difference in resistin levels. Similarly, GGT was associated with higher levels of hs-CRP whereas no association was observed between GGT and adipocytokines.
Conclusion: These findings suggest that overall antioxidant capacity of diet and low levels of UA are associated with circulating adipocytokines whereas no consistent association was found with hs-CRP.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: