Association between the use of magnesium sulfate as neuroprotector in prematurity and the neonatal hemodynamic effects.

Autor: Nunes RD; a Graduate Program in Health Sciences , Universidade do Sul de Santa Catarina , Palhoca , Brazil., Schutz FD; a Graduate Program in Health Sciences , Universidade do Sul de Santa Catarina , Palhoca , Brazil., Traebert JL; a Graduate Program in Health Sciences , Universidade do Sul de Santa Catarina , Palhoca , Brazil.
Jazyk: angličtina
Zdroj: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2018 Jul; Vol. 31 (14), pp. 1900-1905. Date of Electronic Publication: 2017 Jun 02.
DOI: 10.1080/14767058.2017.1332033
Abstrakt: Purpose: Cerebral palsy is often associated with prematurity and magnesium sulfate (MgSO 4 ) has been used as a neuroprotector, with favorable results. However, its mechanism of action has not been fully elucidated. This study aimed to evaluate the association between MgSO 4 at the imminent premature delivery and neonatal hemodynamic effects.
Materials and Methods: A cross-sectional study involving 94 newborns (NB) between 24 and 32 weeks at a Brazilian hospital was performed. Bivariate analysis between the use or the non-use of MgSO 4 and hemodynamic characteristics was performed, using the Chi-square test.
Results: NB were evaluated between those who received MgSO 4 (27.7) and those who did not (72.3%). Normal heart rate was verified in 62.8% of NB, normal respiratory rate in 70.2%, and normal temperature in 22.3%. Oxygen saturation higher or equal than 95% was evidenced in 85.1% of NB, normal hemoglucotest in 74.5%, and hemoglobin greater or equal than 16.4 g/dL in 30.9%. Non-invasive ventilation was performed in 48.9% of NB, while 51.1% were submitted to endotracheal ventilation. There was no significance relation detected between the use of MgSO 4 and the hemodynamic characteristics.
Conclusions: MgSO 4 does not appear to influence hemodynamic factors as a cause of the neuroprotection in premature NB.
Databáze: MEDLINE
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