Uric acid and blood pressure: exploring the role of uric acid production in The Maastricht Study.

Autor:	Scheepers LEJM; aDivision of Rheumatology, Department of Internal Medicine, Maastricht University Medical Centre bCAPHRI School for Public Health and Primary Care cCARIM School for Cardiovascular Diseases dDepartment of Epidemiology, Maastricht University eDepartment of Internal Medicine fHeart and Vascular Centre, Maastricht University Medical Centre gMaCSBio Maastricht Centre for Systems Biology, Maastricht University, Maastricht, The Netherlands., Boonen A, Dagnelie PC, Schram MT, van der Kallen CJH, Henry RMA, Kroon AA, Stehouwer CDA, Arts ICW
Jazyk:	angličtina
Zdroj:	Journal of hypertension [J Hypertens] 2017 Oct; Vol. 35 (10), pp. 1968-1975.
DOI:	10.1097/HJH.0000000000001417
Abstrakt:	Objective: Accumulation of reactive oxygen species by increased uric acid production has been suggested as a possible underlying mechanism for the association between uric acid and high blood pressure (BP). We, therefore, investigated the association between serum uric acid concentration and 24-h urinary uric acid excretion, as proxy for uric acid production, with ambulatory 24-h blood pressure and hypertension. Methods: Cross-sectional analyses were conducted among 2555 individuals [52% men, mean age 60.0 ± 8.2 years; 27% type 2 diabetes (by design)] from The Maastricht Study. Multivariable regression analyses were performed to investigate the association of serum uric acid and 24-h urinary uric acid excretion with 24-h pulse pressure, 24-h mean arterial pressure (MAP), and hypertension. Results: After adjustment for traditional hypertension risk factors, serum uric acid concentration (per SD of 81 μmol/l) was associated with higher 24-h MAP [β 0.63 mmHg; confidence interval (CI) 0.27-1.00] and positively associated with hypertension (odds ratio 1.43; CI 1.27-1.61). Urinary uric acid excretion (per SD of 140 mg/day/1.73 m) was associated with higher 24-h MAP (β 0.79 mmHg; CI 0.46-1.12) and with hypertension (odds ratio 1.13; CI 1.02-1.25). There was no significant association between serum and 24-h urinary uric acid excretion with 24-h pulse pressure. There was no interaction with sex or age for the aforementioned associations. Conclusion: Higher serum and urinary uric acid concentrations were associated with higher 24-h MAP and hypertension. These results suggest that serum and 24-urinary uric acid concentrations, the latter as proxy for uric acid production are, independent of each other, associated with BP and hypertension.
Databáze:	MEDLINE
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