QT prolongation is associated with increased mortality in end stage liver disease.

Autor:	Kim SM; Sun Moon Kim, Bennet George, Brian Delisle, Yousef Darrat, Gustavo Morales, Samy-Claude Elayi, Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40509, United States., George B; Sun Moon Kim, Bennet George, Brian Delisle, Yousef Darrat, Gustavo Morales, Samy-Claude Elayi, Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40509, United States., Alcivar-Franco D; Sun Moon Kim, Bennet George, Brian Delisle, Yousef Darrat, Gustavo Morales, Samy-Claude Elayi, Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40509, United States., Campbell CL; Sun Moon Kim, Bennet George, Brian Delisle, Yousef Darrat, Gustavo Morales, Samy-Claude Elayi, Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40509, United States., Charnigo R; Sun Moon Kim, Bennet George, Brian Delisle, Yousef Darrat, Gustavo Morales, Samy-Claude Elayi, Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40509, United States., Delisle B; Sun Moon Kim, Bennet George, Brian Delisle, Yousef Darrat, Gustavo Morales, Samy-Claude Elayi, Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40509, United States., Hundley J; Sun Moon Kim, Bennet George, Brian Delisle, Yousef Darrat, Gustavo Morales, Samy-Claude Elayi, Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40509, United States., Darrat Y; Sun Moon Kim, Bennet George, Brian Delisle, Yousef Darrat, Gustavo Morales, Samy-Claude Elayi, Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40509, United States., Morales G; Sun Moon Kim, Bennet George, Brian Delisle, Yousef Darrat, Gustavo Morales, Samy-Claude Elayi, Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40509, United States., Elayi SC; Sun Moon Kim, Bennet George, Brian Delisle, Yousef Darrat, Gustavo Morales, Samy-Claude Elayi, Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40509, United States., Bailey AL; Sun Moon Kim, Bennet George, Brian Delisle, Yousef Darrat, Gustavo Morales, Samy-Claude Elayi, Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40509, United States.
Jazyk:	angličtina
Zdroj:	World journal of cardiology [World J Cardiol] 2017 Apr 26; Vol. 9 (4), pp. 347-354.
DOI:	10.4330/wjc.v9.i4.347
Abstrakt:	Aim: To determine the prevalence of QT prolongation in a large series of end stage liver disease (ESLD) patients and its association to clinical variables and mortality. Methods: The QT interval was measured and corrected for heart rate for each patient, with a prolonged QT cutoff defined as QT > 450 ms for males and QT > 470 ms for females. Multiple clinical variables were evaluated including sex, age, serum sodium, international normalized ratio, creatinine, total bilirubin, beta-blocker use, Model for End-Stage Liver Disease (MELD), MELD-Na, and etiology of liver disease. Results: Among 406 ESLD patients analyzed, 207 (51.0%) had QT prolongation. The only clinical variable associated with QT prolongation was male gender (OR = 3.04, 95%CI: 2.01-4.60, P < 0.001). During the study period, 187 patients (46.1%) died. QT prolongation was a significant independent predictor of mortality (OR = 1.69, 95%CI: 1.03-2.77, P = 0.039). In addition, mortality was also associated with viral etiology of ESLD, elevated MELD score and its components ( P < 0.05 for all). No significant reversibility in the QT interval was seen after liver transplantation. Conclusion: QT prolongation was commonly encountered in an ESLD population, especially in males, and served as a strong independent marker for increased mortality in ESLD patients. Competing Interests: Conflict-of-interest statement: The authors of this manuscript have no conflict of interest to disclose.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu