| Autor: |
Heim LR; 1 Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University , Tel Aviv, Israel .; 2 Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University , Tel Aviv, Israel ., Bader M; 1 Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University , Tel Aviv, Israel ., Edut S; 1 Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University , Tel Aviv, Israel ., Rachmany L; 1 Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University , Tel Aviv, Israel ., Baratz-Goldstein R; 1 Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University , Tel Aviv, Israel ., Lin R; 1 Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University , Tel Aviv, Israel ., Elpaz A; 1 Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University , Tel Aviv, Israel ., Qubty D; 1 Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University , Tel Aviv, Israel ., Bikovski L; 6 The Myers Neuro-Behavioral Core Facility, Sackler School of Medicine, Tel Aviv University , Tel Aviv, Israel ., Rubovitch V; 1 Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University , Tel Aviv, Israel ., Schreiber S; 3 Department of Psychiatry, Tel Aviv Sourasky Medical Center , Tel Aviv, Israel .; 4 Sagol School of Neuroscience, Tel Aviv University , Tel Aviv, Israel ., Pick CG; 1 Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University , Tel Aviv, Israel .; 4 Sagol School of Neuroscience, Tel Aviv University , Tel Aviv, Israel .; 5 The Dr. Miriam and Sheldon G. Adelson Chair and Center for the Biology of Addictive Diseases, Tel Aviv University , Tel Aviv, Israel . |
| Abstrakt: |
The present study was designed to tackle two notorious features of mild traumatic brain injury (mTBI)-heterogeneity and invisibility-by characterizing the full scope of mTBI symptoms. Mice were exposed to brain injuries of different intensities utilizing a weight-drop model (10, 30, 50, and 70 g) and subsequently subjected to a comprehensive battery of behavioral tests at different time points and immunohistochemical examination of cortical slices. Whereas the physiological, neurological, emotional, and motor function of mTBI mice (i.e., their well-being) remained largely intact, cognitive deficits were identified by the y-maze and novel object recognition. Results from these two cognitive tests were combined and a dose-response relationship was established between injury intensity and cognitive impairment, ranging from an 85% decline after a 70-g impact (p < 0.001) to a 20% decline after a 10-g impact (essentially no effect). In addition, higher intensities of injury were accompanied by decreased expression of axonal and synaptic markers. Thus, our mTBI mice showed a clear discrepancy between performance (poor cognitive function) and appearance (healthy demeanor). This is of major concern given that diagnosis of mTBI is established on the presence of clinical symptoms and emphasizes the need for an alternative diagnostic modality. |
