1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery.
| Autor: | Kirichok AA; Enamine Ltd./Bienta, Chervonotkatska 78, 02094, Kyiv, Ukraine., Shton I; Enamine Ltd./Bienta, Chervonotkatska 78, 02094, Kyiv, Ukraine., Kliachyna M; Enamine Ltd./Bienta, Chervonotkatska 78, 02094, Kyiv, Ukraine., Pishel I; Enamine Ltd./Bienta, Chervonotkatska 78, 02094, Kyiv, Ukraine., Mykhailiuk PK; Taras Shevchenko National University of Kyiv, Chemistry Department, Volodymyrska 64, 01601, Kyiv, Ukraine.; Enamine Ltd./Bienta, Chervonotkatska 78, 02094, Kyiv, Ukraine. |
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| Jazyk: | angličtina |
| Zdroj: | Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Jul 17; Vol. 56 (30), pp. 8865-8869. Date of Electronic Publication: 2017 Jun 19. |
| DOI: | 10.1002/anie.201703801 |
| Abstrakt: | The 2-substituted piperidine core is found in drugs (18 FDA-approved drugs), however, their spirocyclic analogues remain unknown. Described here is the synthesis of spirocyclic analogues for 2-substituted piperidines and a demonstration of their validation in drug discovery. (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.) |
| Databáze: | MEDLINE |
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