[Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia].

Autor:	Mendzheritsky AM; D. I. Ivanovsky Academy of Biology and Biotechnology of South Federal University, Rostov-on-Don, 344000, Russian Federation; karantyshgv@mail.ru., Karantysh GV; D. I. Ivanovsky Academy of Biology and Biotechnology of South Federal University, Rostov-on-Don, 344000, Russian Federation; karantyshgv@mail.ru., Ryzhak GA; Saint-Petersburg Institute of Bioregulation and Gerontology, Saint-Petersburg, 197110, Russian Federation., Prokofiev VN; D. I. Ivanovsky Academy of Biology and Biotechnology of South Federal University, Rostov-on-Don, 344000, Russian Federation; karantyshgv@mail.ru.
Jazyk:	ruština
Zdroj:	Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2015; Vol. 28 (3), pp. 532-539.
Abstrakt:	The research of Cortexin and Pinealon within two models of stress, acute hypobaric hypoxia and mild hypothermia, within 18-month aged rats has been held. The peculiarities of peptide preparations' influence on behavior and neurochemical indeces have been identified. Cortexin shows a more pronounced effect on free radical processes and caspase 3 activity in brain than Pinealon. Both preparations forward an accumulation of adrenergic mediator within rats' brains in the model of acute hypobaric hypoxia, as well as serotonin within cerebrum cortex in the model of mild hypothermia, which may underlie their geroprotective effects.
Databáze:	MEDLINE
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