Granulomatous interstitial nephritis in a renal allograft.

Autor: Nunota N; Division of Nephrology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan., Honda H; Division of Nephrology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. hondah@med.showa-u.ac.jp., Shibata T; Division of Nephrology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan., Yoshitake O; Division of General and Gastroenterological Surgery, Department of Surgery, Showa University School of Medicine, Tokyo, Japan., Murakami M; Division of General and Gastroenterological Surgery, Department of Surgery, Showa University School of Medicine, Tokyo, Japan., Sanada D; Division of Nephrology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan., Yokochi A; Division of Nephrology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan., Kato N; Division of Nephrology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan., Kuroki A; Division of Nephrology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan., Honda K; Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan., Yamaguchi Y; Yamaguchi Pathology Laboratory, Chiba, Japan., Sugisaki T; Division of Nephrology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan., Akizawa T; Division of Nephrology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
Jazyk: angličtina
Zdroj: CEN case reports [CEN Case Rep] 2012 May; Vol. 1 (1), pp. 12-15. Date of Electronic Publication: 2012 Mar 17.
DOI: 10.1007/s13730-012-0005-6
Abstrakt: We describe a middle-aged woman in whom granulomatous interstitial nephritis (GIN) developed in a renal allograft. She had undergone bowel resection due to an uncertain diagnosis of active granulomatous bowel disease 30 years earlier. Thereafter, frequent hyperoxaluria as well as calcium oxalate stone and recurrent urinary tract infections had resulted in a progressive deterioration in kidney function over a period of 20 years. She underwent living donor kidney transplantation; however, her kidney function progressively deteriorated, despite transplantation. A biopsy of the renal allograft revealed GIN with granulomatous vasculitis accompanied by calcium oxalate crystals. These as well as the laboratory findings indicated a diagnosis of sarcoidosis. We considered that the aggravated granulomatous inflammation on the allograft was caused by recurrent sarcoidosis accompanied by hyperoxaluria.
Databáze: MEDLINE
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