Antinociceptive effect of the agonist of 5-HT1A receptors buspirone in the model of abdominal pain in dogs.

Autor: Lyubashina OA; Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. olga@kolt.infran.ru., Busygina II; Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia., Panteleev SS; Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia., Nozdrachev AD; Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Jazyk: angličtina
Zdroj: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections [Dokl Biol Sci] 2017 Mar; Vol. 473 (1), pp. 46-49. Date of Electronic Publication: 2017 May 16.
DOI: 10.1134/S0012496617020119
Abstrakt: We have demonstrated that activation of 5-HT1A receptors with buspirone promotes visceral analgesia in awake dogs. The administration of 0.035 mg/kg (i.m.) of the drug caused depression of viscero-motor (contraction of the abdominal muscles) and pressor (increase in the heart rate) responses to noxious distension of the large intestine. An increase in the dose to 0.07 and 0.14 mg/kg did not enhance the antinociceptive effect of buspirone but triggered basal tachycardia. The obtained results provide evidence of the inhibitory role of 5-HT1A receptors in modulating visceral pain sensitivity and the possibility of an exciting effect of their activation on the cardiovascular system.
Databáze: MEDLINE
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