Influence of Diet in Multiple Sclerosis: A Systematic Review.

Autor:	Bagur MJ; Department Science and Technology and Genetics Agroforestal, University of Castilla La-Mancha, Campus Universitario, Albacete, Spain., Murcia MA; Department of Food Science, Regional Campus of International Excellence 'Campus Mare Nostrum,' University of Murcia, Murcia, Spain.; CIBEROBN CB12/03/30038 (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain; and., Jiménez-Monreal AM; Department of Food Science, Regional Campus of International Excellence 'Campus Mare Nostrum,' University of Murcia, Murcia, Spain.; CIBEROBN CB12/03/30038 (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain; and., Tur JA; CIBEROBN CB12/03/30038 (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain; and.; Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands, Palma de Mallorca, Spain., Bibiloni MM; CIBEROBN CB12/03/30038 (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain; and.; Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands, Palma de Mallorca, Spain., Alonso GL; Department Science and Technology and Genetics Agroforestal, University of Castilla La-Mancha, Campus Universitario, Albacete, Spain., Martínez-Tomé M; Department of Food Science, Regional Campus of International Excellence 'Campus Mare Nostrum,' University of Murcia, Murcia, Spain; mmtome@um.es.; CIBEROBN CB12/03/30038 (Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain; and.
Jazyk:	angličtina
Zdroj:	Advances in nutrition (Bethesda, Md.) [Adv Nutr] 2017 May 15; Vol. 8 (3), pp. 463-472. Date of Electronic Publication: 2017 May 15 (Print Publication: 2017).
DOI:	10.3945/an.116.014191
Abstrakt:	Nutrition is considered to be a possible factor in the pathogenesis of the neurological disease multiple sclerosis (MS). Nutrition intervention studies suggest that diet may be considered as a complementary treatment to control the progression of the disease; a systematic review of the literature on the influence of diet on MS was therefore conducted. The literature search was conducted by using Medlars Online International Literature (MEDLINE) via PubMed and Scopus. Forty-seven articles met the inclusion criteria. The reviewed articles assessed the relations between macro- and micronutrient intakes and MS incidence. The patients involved used alternative therapies (homeopathy), protocolized diets that included particular foods (herbal products such as grape seed extract, ginseng, blueberries, green tea, etc.), or dietary supplements such as vitamin D, carnitine, melatonin, or coenzyme Q10. Current studies suggest that high serum concentrations of vitamin D, a potent immunomodulator, may decrease the risk of MS and the risk of relapse and new lesions, while improving brain lesions and timed tandem walking. Experimental evidence suggests that serum vitamin D concentration is lower during MS relapses than in remission and is associated with a greater degree of disability [Expanded Disability Status Scale (EDSS) score >3]. The findings suggest that circulating vitamin D concentrations can be considered a biomarker of MS and supplemental vitamin D can be used therapeutically. Other studies point to a negative correlation between serum vitamin B-12 concentrations and EDSS score. Vitamin B-12 has fundamental roles in central nervous system function, especially in the methionine synthase-mediated conversion of homocysteine to methionine, which is essential for DNA and RNA synthesis. Therefore, vitamin B-12 deficiency may lead to an increase in the concentration of homocysteine. Further research is clearly necessary to determine whether treatment with vitamin B-12 supplements delays MS progression. Competing Interests: 2: Author disclosures: MJ Bagur, MA Murcia, AM Jiménez-Monreal, JA Tur, MM Bibiloni, GL Alonso, and M Martínez-Tomé, no conflicts of interest. (© 2017 American Society for Nutrition.)
Databáze:	MEDLINE
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