Regulatory B cells in rheumatoid arthritis: Alterations in patients receiving anti-TNF therapy.

Autor: Bankó Z; Department of Immunology, Eötvös Loránd University, Pázmány Péter sétány 1/c, Budapest 1117, Hungary., Pozsgay J; Department of Immunology, Eötvös Loránd University, Pázmány Péter sétány 1/c, Budapest 1117, Hungary., Gáti T; Buda Hospital of Hospitaller Brothers of St. John, Frankel Leó út 17-19, Budapest 1027, Hungary., Rojkovich B; Buda Hospital of Hospitaller Brothers of St. John, Frankel Leó út 17-19, Budapest 1027, Hungary. Electronic address: rojkovich.b@iragalmas.hu., Ujfalussy I; Medical Centre, Hungarian Defense Forces, Dózsa György út 112, Budapest 1062, Hungary., Sármay G; Department of Immunology, Eötvös Loránd University, Pázmány Péter sétány 1/c, Budapest 1117, Hungary. Electronic address: sarmayg@ttk.elte.hu.
Jazyk: angličtina
Zdroj: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2017 Nov; Vol. 184, pp. 63-69. Date of Electronic Publication: 2017 May 12.
DOI: 10.1016/j.clim.2017.05.012
Abstrakt: Cytokines, including tumor necrosis factor alpha (TNFα) are involved in Rheumatoid arthritis (RA) pathogenesis by augmenting autoimmunity, sustaining long term inflammation in the synovium, and promoting joint damage. Anti-TNF therapy is one of the most efficient and widely used therapies for RA, although its mechanism is not clarified yet. Earlier we demonstrated that RA patients have a reduced number of IL-10 producing regulatory B cells (B10 cells) as compared to healthy individuals and they are functionally impaired. Our aim was to study the influence of anti-TNF therapy on B10 cells in RA, to follow the alteration of B cell activation markers (CD25, CD69) and to monitor the level of citrullinated peptid-specific antibodies and the secreted IL-10 in patients' sera during the therapy. We have observed that at six month after starting the therapy the frequency of B10 cells remarkably increased, while the expression of the activation marker, CD69 decreased on B cells. In contrast, serum levels of IL-10 and anti-citrullinated peptide antibodies did not change post-treatment.
Conclusion: The reduced activation state of B cells and the increasing number of regulatory B10. cells might contribute to the therapeutic efficacy of anti-TNF agents in RA.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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