First report of NDM-1-producing clinical isolate of Leclercia adecarboxylata in Spain.

Autor: Riazzo C; Department of Microbiology, Virgen de las Nieves University Hospital-ibs, Granada, Spain. Electronic address: riazzoc@gmail.com., López-Cerero L; Department of Microbiology, Virgen Macarena University Hospital, Seville, Spain., Rojo-Martín MD; Department of Microbiology, Virgen de las Nieves University Hospital-ibs, Granada, Spain., Hoyos-Mallecot Y; Bacteriology-Hygiene unit, Assistance Publique/Hôpitaux de Paris (AP-PH), Bicêtre Hospital, Le Kremlin-Bicêtre, France; Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-producing Enterobacteriaceae, Le Kremlin-Bicêtre, France; EA7361 'Structure, dynamic, function and expression of broad spectrum β-lactamases', Université Paris-Sud, Université Paris-Saclay, LabEx LERMIT, Faculty of Medicine, Le Kremlin-Bicêtre, France., Fernández-Cuenca F; Department of Microbiology, Virgen Macarena University Hospital, Seville, Spain., Martín-Ruíz JL; Department of Preventive Medicine, Virgen de las Nieves University Hospital, Granada, Spain., Pascual-Hernández Á; Department of Microbiology, Virgen Macarena University Hospital, Seville, Spain., Naas T; Bacteriology-Hygiene unit, Assistance Publique/Hôpitaux de Paris (AP-PH), Bicêtre Hospital, Le Kremlin-Bicêtre, France; Associated French National Reference Center for Antibiotic Resistance: Carbapenemase-producing Enterobacteriaceae, Le Kremlin-Bicêtre, France; EA7361 'Structure, dynamic, function and expression of broad spectrum β-lactamases', Université Paris-Sud, Université Paris-Saclay, LabEx LERMIT, Faculty of Medicine, Le Kremlin-Bicêtre, France; Joint Research Unit EERA «Evolution and Ecology of Resistance to Antibiotics», Institut Pasteur - APHP - Université Paris Sud, Paris, France., Navarro-Marí JM; Department of Microbiology, Virgen de las Nieves University Hospital-ibs, Granada, Spain.
Jazyk: angličtina
Zdroj: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2017 Jul; Vol. 88 (3), pp. 268-270. Date of Electronic Publication: 2017 May 03.
DOI: 10.1016/j.diagmicrobio.2017.04.013
Abstrakt: We describe the case of NDM-1-producing Leclercia adecarboxylata recovered from the clinical sample of a patient hospitalized for a trauma-related injury to his foot. The isolate was resistant to all beta-lactams, quinolones, trimetroprim-sulfametoxazol, gentamicin and tobramicyn. The bla NDM-1 gene was located in a conjugative plasmid that also contained the bla SHV-12 gene and was preceded by a disrupted insertion sequence of ISAba125. The plasmid belongs to the incompatibility group X3, which is known to be an important vector for NDM-1 dissemination in China. This is the first reported case of NDM-1L. adecarboxylata in our country and evidences that species of uncertain clinical relevance can act as hidden sources of clinically important resistance determinants.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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