Seizures Related to Hypomagnesemia: A Case Series and Review of the Literature.

Autor:	Chen BB; Department of Pediatrics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada., Prasad C; Department of Pediatrics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.; Children's Health Research Institute, London, Ontario, Canada., Kobrzynski M; Department of Pediatrics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada., Campbell C; Department of Pediatrics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.; Children's Health Research Institute, London, Ontario, Canada.; Department of Epidemiology and Clinical Neurological Sciences, Western University, London, Ontario, Canada., Filler G; Department of Pediatrics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.; Children's Health Research Institute, London, Ontario, Canada.; Department of Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.; Department of Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	Child neurology open [Child Neurol Open] 2016 Oct 27; Vol. 3, pp. 2329048X16674834. Date of Electronic Publication: 2016 Oct 27 (Print Publication: 2016).
DOI:	10.1177/2329048X16674834
Abstrakt:	Objective: Childhood seizures have various nonneurological etiologies. The patient's magnesium levels should be measured when evaluating afebrile seizures. The purpose of the current case series is to describe a systematic approach for diagnosing hypomagnesemia using 3 recent patient cases. Methods: This case series describes 3 patients with unprovoked hypomagnesemia-associated seizures. The authors describe the differential diagnosis, pathophysiology, and the workup of hypomagnesemia-associated seizures. Results: Hypomagnesemia contributed to the cause of the seizures in all 3 cases. Various causes of hypomagnesemia were investigated, including genetic etiologies. All 3 patients were maintained at a magnesium level >0.65 mmol/L, which improved or eliminated the seizures. Significance: Magnesium levels should always be measured when trying to determine the etiology of seizures. Hypomagnesemia and afebrile seizures should be treated with the goal of maintaining a magnesium concentration >0.65 mmol/L. Although rare, genetic causes of hypomagnesemia should be considered, once common causes of hypomagnesemia are ruled out. Competing Interests: Author Contributions: BBC and MK drafted the manuscript, reviewed and revised the manuscript, and approved the final manuscript as submitted. CP reviewed and revised the manuscript and approved the final manuscript as submitted. CC provided his expertise for components of the manuscript, reviewed and revised the manuscript, and approved the final manuscript as submitted. GF conceptualized the idea for the manuscript, provided his expertise for components of the manuscript, drafted the manuscript, reviewed and revised the manuscript, and approved the final manuscript as submitted. Declaration of Conflicting Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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