The effect of maximal vs submaximal exertion on postprandial lipid levels in individuals with and without coronary heart disease.
Autor: | Aronov DM; National Research Center for Preventive Medicine, Moscow, Russia., Bubnova MG; National Research Center for Preventive Medicine, Moscow, Russia., Perova NV; National Research Center for Preventive Medicine, Moscow, Russia., Orekhov AN; National Research Center for Preventive Medicine, Moscow, Russia; Institute for Atherosclerosis, Skolkovo Innovative Center, Moscow, Russia; Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia; Department of Biophysics, Biological Faculty, Moscow State University, Moscow, Russia., Bobryshev YV; Institute for Atherosclerosis, Skolkovo Innovative Center, Moscow, Russia; Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia; Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia; School of Medicine, University of Western Sydney, Campbelltown, NSW, Australia. Electronic address: y.bobryshev@mail.ru. |
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Jazyk: | angličtina |
Zdroj: | Journal of clinical lipidology [J Clin Lipidol] 2017 Mar - Apr; Vol. 11 (2), pp. 369-376. Date of Electronic Publication: 2017 Jan 18. |
DOI: | 10.1016/j.jacl.2017.01.007 |
Abstrakt: | Background: Decisions about fat consumption and levels of physical activity are among the everyday choices we make in life and risk of coronary heart disease (CHD) can be affected by those choices. Objective: The purpose of this study was to investigate the influence of a standard fat load combined with physical exertion of different intensities on the plasma lipid profile of CHD patients and CHD-free individuals. Methods: This study looked at the influence of different intensities of physical exercise on postprandial lipid metabolism in 20 healthy men and 36 men with diagnosis of CHD. Venous blood samples were obtained after overnight fasting, 3 hours after standard fat load (before the physical load), and immediately after maximal or submaximal physical exercise on bicycle ergometer. Results: After fat load total cholesterol (TC) concentration did not change in either group. However, after the addition of maximal exercise, TC, triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein (Apo) B increased significantly (P < .01) in both groups. After fat load and maximal exercise, there was no change in high-density lipoprotein cholesterol (HDL-C) in healthy men, but in men with CHD, HDL-C fell significantly (P < .01); and Apo AI rose in healthy men (P < .01) but dropped significantly (P < .01) in men with CHD. Submaximal physical exercise (60% of max VO Conclusions: This study demonstrates that moderate exercise is beneficial in improving postprandial lipid abnormalities in both CHD and CHD-free subjects after fatty meal preload. In addition, maximal exercise demonstrated evidence of increase of lipid abnormalities in both CHD and CHD-free individuals under similar conditions of fatty meal preload. (Copyright © 2017 National Lipid Association. Published by Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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