Cranberry (Vaccinium macrocarpon) extract treatment improves triglyceridemia, liver cholesterol, liver steatosis, oxidative damage and corticosteronemia in rats rendered obese by high fat diet.

Autor: Peixoto TC; Laboratory of Endocrine Physiology, Departamento de Ciências Fisiológicas, 5o andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil., Moura EG; Laboratory of Endocrine Physiology, Departamento de Ciências Fisiológicas, 5o andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil., de Oliveira E; Laboratory of Endocrine Physiology, Departamento de Ciências Fisiológicas, 5o andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil., Soares PN; Laboratory of Endocrine Physiology, Departamento de Ciências Fisiológicas, 5o andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil., Guarda DS; Laboratory of Endocrine Physiology, Departamento de Ciências Fisiológicas, 5o andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil., Bernardino DN; Laboratory of Endocrine Physiology, Departamento de Ciências Fisiológicas, 5o andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil., Ai XX; Laboratory of Endocrine Physiology, Departamento de Ciências Fisiológicas, 5o andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil., Rodrigues VDST; Laboratory of Endocrine Physiology, Departamento de Ciências Fisiológicas, 5o andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil., de Souza GR; Department of Program of Natural Products, Phytochemical Analysis Laboratory, Institute for Natural Products Research, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., da Silva AJR; Department of Program of Natural Products, Phytochemical Analysis Laboratory, Institute for Natural Products Research, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Figueiredo MS; Laboratory of Endocrine Physiology, Departamento de Ciências Fisiológicas, 5o andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil., Manhães AC; Laboratory of Neurophysiology, Departamento de Ciências Fisiológicas, 5o andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil., Lisboa PC; Laboratory of Endocrine Physiology, Departamento de Ciências Fisiológicas, 5o andar, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-031, Brazil. pclisboa@uerj.br.
Jazyk: angličtina
Zdroj: European journal of nutrition [Eur J Nutr] 2018 Aug; Vol. 57 (5), pp. 1829-1844. Date of Electronic Publication: 2017 May 13.
DOI: 10.1007/s00394-017-1467-2
Abstrakt: Purpose: Obese individuals have higher production of reactive oxygen species, which leads to oxidative damage. We hypothesize that cranberry extract (CE) can improve this dysfunction in HFD-induced obesity in rats since it has an important antioxidant activity. Here, we evaluated the effects of CE in food intake, adiposity, biochemical and hormonal parameters, lipogenic and adipogenic factors, hepatic morphology and oxidative balance in a HFD model.
Methods: At postnatal day 120 (PN120), male Wistar rats were assigned into two groups: (1) SD (n = 36) fed with a standard diet and (2) HFD (n = 36), fed with a diet containing 44.5% (35.2% from lard) energy from fat. At PN150, 12 animals from SD and HFD groups were killed while the others were subdivided into four groups (n = 12/group): animals that received 200 mg/kg cranberry extract (SD CE, HFD CE) gavage/daily/30 days or water (SD, HFD). At PN180, animals were killed.
Results: HFD group showed higher body mass and visceral fat, hypercorticosteronemia, higher liver glucocorticoid sensitivity, cholesterol and triglyceride contents and microsteatosis. Also, HFD group had higher lipid peroxidation (plasma and tissues) and higher protein carbonylation (liver and adipose tissue) compared to SD group. HFD CE group showed lower body mass gain, hypotrygliceridemia, hypocorticosteronemia, and lower hepatic cholesterol and fatty acid synthase contents. HFD CE group displayed lower lipid peroxidation, protein carbonylation (liver and adipose tissue) and accumulation of liver fat compared to HFD group.
Conclusion: Although adiposity was not completely reversed, cranberry extract improved the metabolic profile and reduced oxidative damage and steatosis in HFD-fed rats, which suggests that it can help manage obesity-related disorders.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje