Expression of aromatase and estrogen receptors in lumbar motoneurons of mice.

Autor: Ji YX; Department of Neurology, The Second Hospital of Hebei Medical University, West Heping Road 215, Shijiazhuang, Hebei 057100, PR China. Electronic address: jiyingxiao2006@163.com., Zhao M; Department of Neurology, The Second Hospital of Hebei Medical University, West Heping Road 215, Shijiazhuang, Hebei 057100, PR China., Liu YL; Department of Neurology, The Second Hospital of Hebei Medical University, West Heping Road 215, Shijiazhuang, Hebei 057100, PR China; Key Laboratory of Neurology of Hebei Province, West Heping Road 215, Shijiazhuang, Hebei 050000, PR China; Institute of Cardiocerebrovascular Disease, West Heping Road 215, Shijiazhuang, Hebei 050000, PR China. Electronic address: lyldoctor@163.com., Chen LS; Department of Critical Care Medicine, The Second Hospital of Shijiazhuang, West Huaxi Road 53, Shijiazhuang, Hebei 050051, PR China., Hao PL; Department of Neurology, The Second Hospital of Hebei Medical University, West Heping Road 215, Shijiazhuang, Hebei 057100, PR China., Sun C; Department of Neurology, The Second Hospital of Hebei Medical University, West Heping Road 215, Shijiazhuang, Hebei 057100, PR China.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2017 Jul 13; Vol. 653, pp. 7-11. Date of Electronic Publication: 2017 May 10.
DOI: 10.1016/j.neulet.2017.05.017
Abstrakt: Estrogen exerts protective roles in amyotrophic lateral sclerosis (ALS). However, the expression of aromatase (ARO) and estrogen receptors (ERs) in the motoneurons of spinal cord, has not yet been elucidated. By immunohistochemistry, we found that ARO and ERs were present in the ventral horn of adult mice lumbar spinal cord, and colocalized with SMI-32, a motoneuron specific marker. Within motoneurons, we observed that ARO is detected primarily in the cytoplasm, with fewer ARO in the nucleus; ERα and ERβ mainly localized in the nucleus with less in the cytoplasm; while GPR30 is located in soma and processes. In conclusion, we found that ERs and ARO are expressed in the motoneurons of lumbar spinal cord in adult mice. These findings suggest that estrogen may be useful as a promising therapeutic agent for prevention of damage and improvement of locomotor function in ALS.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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