Chemical Imaging by Dissolution Analysis: Localized Kinetics of Dissolution Behavior to Provide Two-Dimensional Chemical Mapping and Tomographic Imaging on a Nanoscale.

Autor:	Reading M; Department of Chemical Sciences, School of Applied Sciences, University of Huddersfield , Queensgate, Huddersfield, HD1 3DH, United Kingdom., Ghori MU; Department of Pharmacy, School of Applied Sciences, University of Huddersfield , Queensgate, Huddersfield, HD1 3DH, United Kingdom., Brown DR; Department of Chemical Sciences, School of Applied Sciences, University of Huddersfield , Queensgate, Huddersfield, HD1 3DH, United Kingdom., Fleming LT; Mechanical and Automotive Engineering, School of Computing and Engineering, University of Huddersfield , Queensgate, Huddersfield, HD1 3DH, United Kingdom., Antonijevic MD; Faculty of Engineering and Science, University of Greenwich , Central Avenue, Chatham Maritime, ME4 4TB, United Kingdom., Grandy DB; Loughborough University , Epinal Way, Loughborough LE11 3TU, United Kingdom., Hourston DJ; Loughborough University , Epinal Way, Loughborough LE11 3TU, United Kingdom., Song M; Loughborough University , Epinal Way, Loughborough LE11 3TU, United Kingdom., Conway BR; Department of Pharmacy, School of Applied Sciences, University of Huddersfield , Queensgate, Huddersfield, HD1 3DH, United Kingdom.
Jazyk:	angličtina
Zdroj:	Analytical chemistry [Anal Chem] 2017 Jun 06; Vol. 89 (11), pp. 5882-5890. Date of Electronic Publication: 2017 May 24.
DOI:	10.1021/acs.analchem.7b00202
Abstrakt:	A new approach to achieving chemical mapping on a nanoscale is described that can provide 2D and tomographic images of surface and near-surface structure. The method comprises dissolving material from the surface of the sample by applying a series of aliquots of solvent, then analyzing their contents after removing them; in between exposures, the surface is imaged with atomic force microscopy. This technique relies on being able to compensate for any drift between images by use of software. It was applied to a blend of two polymers, PMMA and PS. The analytical data identified the material that was dissolved, and the topography images enabled the location of the various materials to be determined by analyzing local dissolution kinetics. The prospects for generalizing the approach are discussed.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu