Epilepsia partialis continua after an anterior circulation ischaemic stroke.

Autor: Bentes C; Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria - CHLN, Lisbon, Portugal.; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Franco AC; Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria - CHLN, Lisbon, Portugal., Peralta AR; Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria - CHLN, Lisbon, Portugal.; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Viana P; Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria - CHLN, Lisbon, Portugal.; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Martins H; Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria - CHLN, Lisbon, Portugal.; Department of Medicine, Hospital de São José - CHLC, Lisboa, Portugal., Morgado C; Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria - CHLN, Lisbon, Portugal.; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Casimiro C; Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria - CHLN, Lisbon, Portugal., Fonseca C; Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria - CHLN, Lisbon, Portugal.; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Geraldes R; Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria - CHLN, Lisbon, Portugal.; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Canhão P; Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria - CHLN, Lisbon, Portugal.; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Pinho E Melo T; Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria - CHLN, Lisbon, Portugal.; Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Paiva T; Electroencephalography and Clinic Neurophysiology Centre (CENC), Lisboa, Portugal., Ferro JM; Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria - CHLN, Lisbon, Portugal.; Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
Jazyk: angličtina
Zdroj: European journal of neurology [Eur J Neurol] 2017 Jul; Vol. 24 (7), pp. 929-934. Date of Electronic Publication: 2017 May 12.
DOI: 10.1111/ene.13310
Abstrakt: Background and Purpose: Although cerebrovascular disorders are the main cause of epilepsia partialis continua (EPC) in adulthood, the frequency of EPC after stroke is unknown. The aim was to prospectively ascertain its frequency 1 year after an ischaemic stroke.
Methods: This was a prospective study of consecutive acute anterior circulation ischaemic stroke patients, previously independent, with an admission National Institutes of Health Stroke Scale score ≥4, an acute ischaemic lesion on imaging and no previous epileptic seizures. During admission patients received standardized diagnostic and medical care and were submitted to a neurophysiological evaluation protocol. One year after stroke, patients were re-evaluated by an epilepsy expert neurologist and performed a video-electroencephalogram with electromyography co-registration whenever myoclonus was observed during neurological examination for jerk-locked back averaging analysis (JLBA). EPC was defined as continuously repeated fragments of epileptic seizures, with preserved consciousness, lasting at least 1 h, and representing locally restricted epileptic activity.
Results: In all, 151 acute anterior circulation stroke patients were consecutively included and prospectively evaluated, but 23 died in the first year. One year after stroke, from 127 patients alive, 117 (92.1%) underwent clinical and neurophysiological evaluation. In two (1.7%) patients, EPC diagnosis was made both by clinical and electroencephalographic criteria, namely JLBA. Both patients had a history of remote symptomatic seizures and one of them acute symptomatic seizures and non-convulsive status epilepticus criteria during the first 7 days after stroke.
Conclusions: Despite its low frequency, the high stroke incidence makes post-stroke EPC relevant. This study draws attention to this recognizable condition with therapeutic and eventually prognostic implications.
(© 2017 EAN.)
Databáze: MEDLINE
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