| Autor: |
Sorlózano-Puerto A; Departamento de Microbiología, Universidad de Granada-ibs.Granada, Granada, Spain., Gómez-Luque JM; UGC de Pediatría, Complejo Hospitalario Universitario de Granada-ibs.Granada, Hospital General Virgen de las Nieves, Granada, Spain., Luna-Del-Castillo JD; Departamento de Bioestadística, Universidad de Granada-ibs.Granada, Granada, Spain., Navarro-Marí JM; Laboratorio de Microbiología, Complejo Hospitalario Universitario de Granada-ibs.Granada, Hospital General Virgen de las Nieves, Granada, Spain., Gutiérrez-Fernández J; Departamento de Microbiología, Universidad de Granada-ibs.Granada, Granada, Spain.; Laboratorio de Microbiología, Complejo Hospitalario Universitario de Granada-ibs.Granada, Hospital General Virgen de las Nieves, Granada, Spain. |
| Jazyk: |
angličtina |
| Zdroj: |
BioMed research international [Biomed Res Int] 2017; Vol. 2017, pp. 4909452. Date of Electronic Publication: 2017 Apr 11. |
| DOI: |
10.1155/2017/4909452 |
| Abstrakt: |
Background. The objective of this study was to identify the bacteria most frequently responsible for urinary tract infection (UTI) in the population of under-2-year-olds in our geographic area and to evaluate the activity of antibiotics widely used for UTI treatment during a 4-year study period. Materials and Methods. A retrospective analysis was conducted of data on the identification and susceptibility of microorganisms isolated in urine samples from children under 2 years of age. Results. A total of 1,045 uropathogens were isolated. Escherichia coli accounted for the majority (60.3%) of these, followed by Enterococcus faecalis (22.4%) and Klebsiella spp. (6.5%). The highest E. coli susceptibility rates (>90%) were to piperacillin-tazobactam, cefuroxime, cefotaxime, ceftazidime, imipenem, gentamicin, nitrofurantoin, and fosfomycin, and the lowest were to amoxicillin-clavulanic acid and cotrimoxazole. Among all bacteria isolated, we highlight the overall high activity of piperacillin-tazobactam, imipenem, nitrofurantoin, and fosfomycin against both community and hospital isolates and the reduced activity of amoxicillin-clavulanic acid, cephalosporins, gentamicin, and cotrimoxazole. There was no significant change in the total activity of any of the studied antibiotics over the 4-year study period. Conclusion. Empiric treatment with amoxicillin-clavulanic acid, cotrimoxazole, cephalosporins, and gentamicin may be inadequate due to their limited activity against uropathogens in our setting. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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