The HLA-DR mediated signalling increases the migration and invasion of melanoma cells, the expression and lipid raft recruitment of adhesion receptors, PD-L1 and signal transduction proteins.

Autor: Costantini F; Istituto di Biomedicina e Immunologia Molecolare 'Alberto Monroy', Consiglio Nazionale delle Ricerche (CNR), Via Ugo La Malfa 153, 90146 Palermo, Italy. Electronic address: francesca.costantini@ibim.cnr.it., Barbieri G; Istituto di Biomedicina e Immunologia Molecolare 'Alberto Monroy', Consiglio Nazionale delle Ricerche (CNR), Via Ugo La Malfa 153, 90146 Palermo, Italy. Electronic address: barbieri@ibim.cnr.it.
Jazyk: angličtina
Zdroj: Cellular signalling [Cell Signal] 2017 Aug; Vol. 36, pp. 189-203. Date of Electronic Publication: 2017 May 08.
DOI: 10.1016/j.cellsig.2017.05.008
Abstrakt: The constitutive expression of Major Histocompatibility Complex (MHC) class II molecules is restricted to professional Antigen-Presenting Cells (APCs), nevertheless almost 50% of melanomas express constitutively the MHC class II molecules. Therefore, in two MHC class II constitutive expressing melanoma cell lines we studied the signalling mediated by the HLA-DR molecules in the aim to understand the consequence of class II mediated signalling on metastatic dissemination of melanoma. In particular, we reported that the HLA-DR mediated signalling play a new role in melanoma progression, increasing the migration and invasion of melanoma cells. Furthermore, we showed that the HLA-DR mediated signalling increases the expression and the lipid raft localisation of class II molecules, PD-L1 receptor, Integrin and CAM adhesion receptors, FAK, AKT and STAT3 signalling proteins. We also showed that the HLA-DR mediated signalling increases the activation of FAK, AKT, ERK, PKC and STAT3 signalling proteins and the expression of ILK, PAX, BRAF, ERK and PKC. Indeed, the results showed suggest that the HLA-DR mediated signalling provides a platform useful to frustrate an effective anti-tumour response and to increase melanoma migration and metastatic dissemination of this cancer.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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