Structural brain abnormalities in patients with type I bipolar disorder and suicidal behavior.

Autor: Duarte DGG; Mental Health Department, Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil. Electronic address: dantegalileu@gmail.com., Neves MCL; Mental Health Department, Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil. Electronic address: mailacln@gmail.com., Albuquerque MR; Federal University of Viçosa, Minas Gerais, Brazil. Electronic address: lin.maicon@gmail.com., Turecki G; McGill Group for Suicide Studies, Department of Psychiatry, McGill University, Montreal, Canada. Electronic address: gustavo.turecki@mcgill.ca., Ding Y; McGill Group for Suicide Studies, Department of Psychiatry, McGill University, Montreal, Canada. Electronic address: yang.ding@mail.mcgill.ca., de Souza-Duran FL; Laboratory of Neuroimaging in Psychiatry (LIM-21), Research in Applied Neuroscience, Support Care of the University of São Paulo (NAPNA-USP), São Paulo, Brazil. Electronic address: fabio.duran@hc.fm.usp.br., Busatto G; Laboratory of Neuroimaging in Psychiatry (LIM-21), Research in Applied Neuroscience, Support Care of the University of São Paulo (NAPNA-USP), São Paulo, Brazil. Electronic address: geraldo.busatto@gmail.com., Correa H; Mental Health Department, Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil. Electronic address: correa@task.com.br.
Jazyk: angličtina
Zdroj: Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2017 Jul 30; Vol. 265, pp. 9-17. Date of Electronic Publication: 2017 May 02.
DOI: 10.1016/j.pscychresns.2017.04.012
Abstrakt: Some studies have identified brain morphological changes in the frontolimbic network (FLN) in bipolar subjects who attempt suicide (SA). The present study investigated neuroanatomical abnormalities in the FLN to find a possible neural signature for suicidal behavior in patients with bipolar disorder type I (BD-I). We used voxel-based morphometry to compare euthymic patients with BD-I who had attempted suicide (n=20), who had not attempted suicide (n=19) and healthy controls (HCs) (n=20). We also assessed the highest medical lethality of their previous SA. Compared to the participants who had not attempted suicide, the patients with BD-I who had attempted suicide exhibited significantly increased gray matter volume (GMV) in the right rostral anterior cingulate cortex (ACC), which was more pronounced and extended further to the left ACC in the high-lethality subgroup (p<0.05, with family-wise error (FWE) correction for multiple comparisons using small-volume correction). GMV in the insula and orbitofrontal cortex was also related to suicide lethality (p<0.05, FWE-corrected). The current findings suggest that morphological changes in the FLN could be a signature of previous etiopathogenic processes affecting regions related to suicidality and its severity in BD-I patients.
(Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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