Baicalin Alleviates Nitroglycerin-induced Migraine in Rats via the Trigeminovascular System.

Autor: Sun YY; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, JS, 210009, China., Zhang WJ; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, JS, 210009, China., Dong CL; The People's Hospital of Zhangqiu, Zhangqiu, 250200, China., Zhang XF; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, JS, 210009, China., Ji J; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, JS, 210009, China., Wang X; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, JS, 210009, China., Wang L; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, JS, 210009, China., Hu WL; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, JS, 210009, China., Du WJ; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, JS, 210009, China., Cui CL; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, JS, 210009, China., Zhang CF; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, JS, 210009, China.; Tang Center of Herbal Medicine Research and Department of Anesthesia & Critical Care, The University of Chicago, Chicago, IL, 60637, USA., Li F; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, JS, 210009, China., Wang CZ; Tang Center of Herbal Medicine Research and Department of Anesthesia & Critical Care, The University of Chicago, Chicago, IL, 60637, USA., Yuan CS; Tang Center of Herbal Medicine Research and Department of Anesthesia & Critical Care, The University of Chicago, Chicago, IL, 60637, USA.
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2017 Jun; Vol. 31 (6), pp. 899-905. Date of Electronic Publication: 2017 May 10.
DOI: 10.1002/ptr.5811
Abstrakt: Migraine is a common neurological disorder with a serious impact on quality of life. The aim of this study was to explore the effect of baicalin on nitroglycerin-induced migraine rats. We carried out a behavioral research within 2 h post-nitroglycerin injection, and blood samples were drawn for measurements of nitric oxide (NO), calcitonin gene-related peptide, and endothelin (ET) levels. Immunohistochemistry was adopted to detect the activation of C-fos immunoreactive neurons in periaqueductal gray. The number, area size, and integrated optical density of C-fos positive cells were measured using Image-Pro Plus. As a result, baicalin administration (0.22 mm/kg) alleviated pain responses of migraine rats. It profoundly decreased NO and calcitonin gene-related peptide levels, increased ET levels, and rebuilt the NO/ET balance in migraine rats. Besides, baicalin pretreatment significantly reduced the number, the stained area size, and integrated optical density value of C-fos positive cells. In brief, this paper supports the possibility of baicalin as a potential migraine pharmacotherapy. Copyright © 2017 John Wiley & Sons, Ltd.
(Copyright © 2017 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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