| Autor: |
Palharini JG; Laboratory of Immunoparasitology 'Dr. Mario Endsfeldz Camargo', Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil., Richter AC; Laboratory of Immunoparasitology 'Dr. Mario Endsfeldz Camargo', Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil., Silva MF; Laboratory of Immunoparasitology 'Dr. Mario Endsfeldz Camargo', Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil., Ferreira FB; Laboratory of Immunoparasitology 'Dr. Mario Endsfeldz Camargo', Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil., Pirovani CP; Biological Sciences Department, State University of Santa CruzIlhéus, Brazil., Naves KSC; Laboratory of Clinical Bacteriology, Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil., Goulart VA; Laboratory of Nanobiotechnology, Institute of Genetics and Biochemistry, Federal University of UberlândiaUberlândia, Brazil., Mineo TWP; Laboratory of Immunoparasitology 'Dr. Mario Endsfeldz Camargo', Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil., Silva MJB; Laboratory of Tumor Biomarkers and Osteoimmunology, Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil., Santiago FM; Laboratory of Immunoparasitology 'Dr. Mario Endsfeldz Camargo', Institute of Biomedical Sciences, Federal University of UberlândiaUberlândia, Brazil. |
| Abstrakt: |
Eutirucallin is a lectin isolated from the latex of Euphorbia tirucalli , a plant known for its medical properties. The present study explores various characteristics of Eutirucallin including stability, cytotoxicity against tumor cells, antimicrobial and antiparasitic activities. Eutirucallin was stable from 2 to 40 days at 4°C, maintained hemagglutinating activity within a restricted range, and showed optimal activity at pH 7.0-8.0. Eutirucallin presented antiproliferative activity for HeLa, PC3, MDA-MB-231, and MCF-7 tumor cells but was not cytotoxic for non-tumorigenic cells such as macrophages and fibroblasts. Eutirucallin inhibited the Ehrlich ascites carcinoma in vivo and it was also observed that Eutirucallin inhibited 62.5% of Escherichia coli growth. Also, Eutirucallin showed to be effective when tested directly against Toxoplasma gondii infection in vitro . Therefore, this study sheds perspectives for pharmacological applications of Eutirucallin. |
