Radical chemo-irradiation using intensity-modulated radiotherapy for locally advanced head and neck cancer in elderly patients: Experience from a tertiary care center in South India.

Autor: Chalissery JR; Department of Radiation Oncology, Amala Institute of Medical Sciences, Thrissur, Kerala, India., Sudheeran PC; Department of Radiation Oncology, Amala Institute of Medical Sciences, Thrissur, Kerala, India., Varghese KM; Department of Radiation Oncology, Amala Institute of Medical Sciences, Thrissur, Kerala, India., Venkatesan K; Department of Radiation Oncology, Amala Institute of Medical Sciences, Thrissur, Kerala, India.
Jazyk: angličtina
Zdroj: Indian journal of cancer [Indian J Cancer] 2016 Oct-Dec; Vol. 53 (4), pp. 483-486.
DOI: 10.4103/ijc.IJC_78_17
Abstrakt: Objective: To assess the feasibility, tolerance and response of radical chemo irradiation using Intensity modulated Radiotherapy [IMRT] in elderly patients [age >65] with locally advanced head and neck cancer.
Material and Methods: Patients aged 65 and above [range 65 to 84years] registered in oncology outpatient unit in our institution between December 2011 to 2014, with stage III and IV head and neck cancer were treated with radical dose of radiotherapy using IMRT and concurrent chemotherapy with cisplatin 40mg/sq.m weekly. Response evaluation and toxicity profile assessment was done 6 to 8 weeks after completion of treatment and 3 monthly thereafter with median follow up of 3 years.
Results: Total number of patients analysed were 47. 43(91.5%) patients tolerated 66-.70Gy of radiotherapy and 4 or more cycles of weekly chemotherapy with cisplatin. First follow up evaluation at 6 to 8 weeks showed 81% patients having complete loco regional response. Grade III skin reaction and mucositis was noticed in 24% and 47% respectively. No grade III neutropenia observed. Median follow up of 3 years showed a complete local control in 53% and overall survival of 60%.
Conclusion: Radical chemo irradiation with IMRT in elderly patients is a feasible option. Long term local control and overall survival benefits needs to be followed up.
Databáze: MEDLINE
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