Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes.

Autor:	Tuttle AH; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada., Tansley S; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada., Dossett K; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada., Tohyama S; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada., Khoutorsky A; Department of Biochemistry McGill University, Montreal, QC H3A 1A3 Canada.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3 Canada., Maldonado-Bouchard S; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada., Stein L; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada., Gerstein L; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada., Crawhall-Duk H; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada., Pearl R; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada., Sukosd M; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada., Leger P; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada., Hardt OM; Centre for Cognitive and Neural Systems, University of Edinburgh, Edinburgh, EH8 9JZ United Kingdom.; The Patrick Wild Centre, University of Edinburgh, Edinburgh, EH8 9JZ United Kingdom., Yachnin D; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada., Austin JS; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada., Chan CM; Department of Psychology, University of Toronto, Mississauga, ON L5L 1C6 Canada., Pooters T; The Patrick Wild Centre, University of Edinburgh, Edinburgh, EH8 9JZ United Kingdom.; Centre for Integrative Physiology University of Edinburgh, Edinburgh, EH8 9XD United Kingdom., Groves I; The Patrick Wild Centre, University of Edinburgh, Edinburgh, EH8 9JZ United Kingdom.; Centre for Integrative Physiology University of Edinburgh, Edinburgh, EH8 9XD United Kingdom., Martin LJ; Department of Psychology, University of Toronto, Mississauga, ON L5L 1C6 Canada., Sonenberg N; Department of Biochemistry McGill University, Montreal, QC H3A 1A3 Canada; jeffrey.mogil@mcgill.ca nahum.sonenberg@mcgill.ca Christos.Gkogkas@ed.ac.uk.; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3 Canada., Gkogkas CG; The Patrick Wild Centre, University of Edinburgh, Edinburgh, EH8 9JZ United Kingdom; jeffrey.mogil@mcgill.ca nahum.sonenberg@mcgill.ca Christos.Gkogkas@ed.ac.uk.; Centre for Integrative Physiology University of Edinburgh, Edinburgh, EH8 9XD United Kingdom., Mogil JS; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada; jeffrey.mogil@mcgill.ca nahum.sonenberg@mcgill.ca Christos.Gkogkas@ed.ac.uk.; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 May 23; Vol. 114 (21), pp. 5515-5520. Date of Electronic Publication: 2017 May 08.
DOI:	10.1073/pnas.1703477114
Abstrakt:	Existing assays of social interaction are suboptimal, and none measures propinquity, the tendency of rodents to maintain close physical proximity. These assays are ubiquitously performed using inbred mouse strains and mutations placed on inbred genetic backgrounds. We developed the automatable tube cooccupancy test (TCOT) based on propinquity, the tendency of freely mobile rodents to maintain close physical proximity, and assessed TCOT behavior on a variety of genotypes and social and environmental conditions. In outbred mice and rats, familiarity determined willingness to cooccupy the tube, with siblings and/or cagemates of both sexes exhibiting higher cooccupancy behavior than strangers. Subsequent testing using multiple genotypes revealed that inbred strain siblings do not cooccupy at higher rates than strangers, in marked contrast to both outbred and rederived wild mice. Mutant mouse strains with "autistic-like" phenotypes ( Fmr1 -/y and Eif4e Ser209Ala) displayed significantly decreased cooccupancy. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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