Optimisation of metabolic criteria in the prognostic assessment in patients with lymphoma. A multicentre study.

Autor:	Del Puig Cózar-Santiago M; Servicio de Medicina Nuclear, ERESA-Hospital General Universitario de Valencia, Valencia, España. Electronic address: mcozar@eresa.com., García-Garzón JR; Unidad PET Esplugues, Cetir-ERESA, Esplugues de Llobregat, Barcelona, España., Moragas-Freixa M; Unidad PET Esplugues, Cetir-ERESA, Esplugues de Llobregat, Barcelona, España., Soler-Peter M; Unidad PET Esplugues, Cetir-ERESA, Esplugues de Llobregat, Barcelona, España., Bassa Massanas P; Unidad PET Esplugues, Cetir-ERESA, Esplugues de Llobregat, Barcelona, España., Sánchez-Delgado M; Servicio de Hematología, Hospital General Universitario de Valencia, Valencia, España., Sanchez-Jurado R; Servicio de Medicina Nuclear, ERESA-Hospital General Universitario de Valencia, Valencia, España., Aguilar-Barrios JE; Servicio de Medicina Nuclear, ERESA-Hospital General Universitario de Valencia, Valencia, España., Sanz-Llorens R; Servicio de Medicina Nuclear, ERESA-Hospital General Universitario de Valencia, Valencia, España., Ferrer-Rebolleda J; Servicio de Medicina Nuclear, ERESA-Hospital General Universitario de Valencia, Valencia, España.
Jazyk:	English; Spanish; Castilian
Zdroj:	Revista espanola de medicina nuclear e imagen molecular [Rev Esp Med Nucl Imagen Mol] 2017 Sep - Oct; Vol. 36 (5), pp. 304-311. Date of Electronic Publication: 2017 May 05.
DOI:	10.1016/j.remn.2017.03.003
Abstrakt:	Objective: To compare sensitivity, specificity and predictive value of Deauville score (DS) vs. ΔSUVmax in interim-treatment PET (iPET) and end-treatment PET (ePET), in patients with diffuse large B cell lymphoma (DLBCL), Hodgkin lymphoma (HL), and follicular lymphoma (FL). Method: Retrospective longitudinal multicentre study including 138 patients (46 DLBCL, 46 HL, 46 FL), on whom 3 18 F-FDG PET/CT were performed: baseline, iPET, and ePET. Visual (DS) and semi-quantitative (ΔSUVmax) parameters were determined for iPET and ePET. Predictive value was determined in relation to disease-free interval. Results: Statistical analysis. iPET for DLBCL, HL, and FL: 1) sensitivity of DS: 76.92/83.33/61.53%; specificity: 78.78/85/81.81%; 2) sensitivity of ΔSUVmax: 53.84/83.33/61.53%; specificity: 87.87/87.50/78.78%. ePET for DLBCL, HL and FL: 1) sensitivity of DS: 61.53/83.33/69.23%; specificity: 90.90/85/87.87%; 2) sensitivity of ΔSUVmax: 69.23/83.33/69.23%; specificity: 90.90/87.50/84.84%. Predictive assessment. iPET study: in DLBCL, DS resulted in 10.3% recurrence of negative iPET, and 17.1% in ΔSUVmax at disease-free interval; in HL, both parameters showed a 2.8% recurrence of negative iPET; in FL, DS resulted in 15.6% recurrence of negative iPET, and 16.1% in ΔSUVmax, with no statistical significance. ePET study: in DLBCL, DS resulted in 14.3% recurrence of negative ePET, and 11.8% in ΔSUVmax at disease-free interval; in HL and FL, both methods showed 2.8 and 12.5% recurrence in negative ePET, respectively. Conclusion: DS and ΔSUVmax did not show significant differences in DLBCL, HL and FL. Their predictive value also did not show significant differences in HL and FL. In DLBCL, DS was higher in iPET, and ΔSUVmax in ePET. (Copyright © 2017 Elsevier España, S.L.U. y SEMNIM. All rights reserved.)
Databáze:	MEDLINE
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