The effects of Alkanna tinctoria Tausch on split-thickness skin graft donor site management: a randomized, blinded placebo-controlled trial.

Autor: Kheiri A; Plastic and Reconstructive Surgery Division, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Amini S; Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran., Javidan AN; Brain and Spinal Injury Research Center, Institute of Neuroscience, Tehran University of Medical Sciences, Tehran, Iran., Saghafi MM; Pharmacology Department, Faculty of Pharmacy, Iran University of Medical Sciences, Tehran, Iran., Khorasani G; Plastic and Reconstructive Surgery Division, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Gakhorasani@yahoo.com.
Jazyk: angličtina
Zdroj: BMC complementary and alternative medicine [BMC Complement Altern Med] 2017 May 08; Vol. 17 (1), pp. 253. Date of Electronic Publication: 2017 May 08.
DOI: 10.1186/s12906-017-1741-0
Abstrakt: Background: A prospective, randomized, placebo-controlled clinical trial was conducted to compare the healing effectiveness of Alkanna tinctoria (L.) Tausch (Boraginaceae) with standard dressing on wound healing at the donor site after removal of the skin graft.
Methods: Enrolled patients were randomly allocated to receive topicalA. tinctoria extract ointment (20%) or standard dressing (dressing with base ointment) daily. Wound healing was assessed using the Bates-Jenson assessment tool at the 2 nd and 4 th weeks after intervention.
Results: Decreases in wound score were significantly greater in the A. tinctoria group compared with the placebo group (P <0.05). The surface areas of graft donor sites in the A. tinctoria group were significantly reduced as compared with the control group at day 28 of the intervention (P < 0.05). The proportion of patients in the A. tinctoria group achieving complete wound healing within 2 to 4 weeks was 50% and 96.66%, respectively, significantly higher than in patients receiving standard care: 0% and 23.3%, respectively.
Conclusions: This clinical study showed that A. tinctoria dressing accelerates wound healing after graft harvesting.
Trial Registration: IRCT ID: IRCT201511165781N2 .
Databáze: MEDLINE
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