Central Nervous System Infection Diagnosis by Next-Generation Sequencing: A Glimpse Into the Future?

Autor:	Mai NTH; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Phu NH; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Nhu LNT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Hong NTT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Hanh NHH; Vietnam National University, Ho Chi Minh City, Vietnam., Nguyet LA; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Phuong TM; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., McBride A; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Ha DQ; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Nghia HDT; Pham Ngoc Thach University, Ho Chi Minh City, Vietnam., Chau NVV; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Thwaites G; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, United Kingdom., Tan LV; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Jazyk:	angličtina
Zdroj:	Open forum infectious diseases [Open Forum Infect Dis] 2017 Mar 04; Vol. 4 (2), pp. ofx046. Date of Electronic Publication: 2017 Mar 04 (Print Publication: 2017).
DOI:	10.1093/ofid/ofx046
Abstrakt:	Japanese encephalitis virus was detected by deep sequencing for the first time in urine of a 16-year-old boy with encephalitis. Seroconversion and polymerase chain reaction analysis confirmed the metagenomics finding. Urine is useful for diagnosis of flaviviral encephalitis, whereas deep sequencing can be a panpathogen assay for the diagnosis of life-threatening infectious diseases.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu PDF