Pericytes are heterogeneous in their origin within the same tissue.

Autor: Dias Moura Prazeres PH; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Sena IFG; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Borges IDT; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., de Azevedo PO; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Andreotti JP; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., de Paiva AE; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., de Almeida VM; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., de Paula Guerra DA; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Pinheiro Dos Santos GS; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Mintz A; Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA., Delbono O; Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, NC, USA., Birbrair A; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: birbrair@icb.ufmg.br.
Jazyk: angličtina
Zdroj: Developmental biology [Dev Biol] 2017 Jul 01; Vol. 427 (1), pp. 6-11. Date of Electronic Publication: 2017 May 04.
DOI: 10.1016/j.ydbio.2017.05.001
Abstrakt: Pericytes heterogeneity is based on their morphology, distribution, and markers. It is well known that pericytes from different organs may have distinct embryonic sources. Yamazaki et al. (2017) using several transgenic mouse model reveal by cell-lineage tracing that pericytes are even more heterogeneous than previously appreciated. This study shows that pericytes from within the same tissue may be heterogeneous in their origin. Remarkably, a subpopulation of embryonic dermal pericytes derives from the hematopoietic lineage, an unexpected source. Reconstructing the lineage of pericytes is central to understanding development, and also for the diagnosis and treatment of diseases in which pericytes play important roles.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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