Impact of adolescent alcohol use across the lifespan: Long-lasting tolerance to high-dose alcohol coupled with potentiated spatial memory impairments to moderate-dose alcohol.

Autor: Matthews DB; Department of Psychology, University of Wisconsin - Eau Claire, Eau Claire, WI, USA. Electronic address: matthedb@uwec.edu., Novier A; Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA., Diaz-Granados JL; Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA., Van Skike CE; Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Ornelas L; Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA., Mittleman G; Department of Psychological Science, Ball State University, Muncie, IN, USA.
Jazyk: angličtina
Zdroj: Alcohol (Fayetteville, N.Y.) [Alcohol] 2017 Jun; Vol. 61, pp. 33-42. Date of Electronic Publication: 2017 May 04.
DOI: 10.1016/j.alcohol.2017.01.012
Abstrakt: Understanding how alcohol exposure during adolescence affects aging is a critical but understudied area. In the present study, male rats were exposed to either alcohol or saline during adolescence, then tested every 4 months following either an ethanol or saline challenge; animals were tested until postnatal day (PD) 532. It was found that long-lasting tolerance to high-dose ethanol exists through the test period, as measured by loss of righting reflex, while tolerance to lower doses of ethanol is not found. In addition, alcohol exposure during adolescence facilitated spatial memory impairments to acute ethanol challenges later in life. The current work demonstrates that exposure to ethanol during adolescent development can produce long-lasting detrimental impairments.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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